Disciformycins A and B: 12-Membered Macrolide Glycoside Antibiotics from the Myxobacterium Pyxidicoccus fallax Active against Multiresistant Staphylococci

被引：52

作者：

Surup, Frank ^{[1
,3
]}

Viehrig, Konrad ^{[2
,3
]}

Mohr, Kathrin I. ^{[1
,3
]}

Herrmann, Jennifer ^{[2
,3
]}

Jansen, Rolf ^{[1
,3
]}

Mueller, Rolf ^{[1
,2
,3
]}

机构：

[1] Helmholtz Ctr Infect Res HZI, Dept Microbial Drugs, D-38124 Braunschweig, Germany

[2] Helmholtz Ctr Infect Res & Pharmaceut Biotechnol, Helmholtz Inst Pharmaceut Res Saarland HIPS, D-66123 Saarbrucken, Germany

[3] German Ctr Infect Res DZIF, Braunschweig, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 49期

关键词：

antibiotics; biosynthesis; myxobacteria; polyketides; secondary metabolites; DOUBLE-BOND MIGRATION; NMR-SPECTROSCOPY; GENE-CLUSTER; POLYKETIDE; IDENTIFICATION; BIOSYNTHESIS; EPOTHILONE; PREDICTION; DISCOVERY;

D O I：

10.1002/anie.201406973

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two macrolide glycosides with a unique scaffold were isolated from cultures of the myxobacterium Pyxidicoccus fallax. Their structures, including absolute configurations, were elucidated by a combination of NMR, MS, degradation, and molecular modeling techniques. Analysis of the proposed biosynthetic gene cluster led to insights into the biosynthesis of the polyketide and confirmed the structure assignment. The more active compound, disciformycin B, potently inhibits methicillin-and vancomycin-resistant Staphylococcus aureus.

引用

页码：13588 / 13591

页数：4

共 33 条

[1] NMR-SPECTROSCOPY IN THE STRUCTURAL ELUCIDATION OF OLIGOSACCHARIDES AND GLYCOSIDES [J].