Costs and cost-effectiveness of cervical cancer screening strategies in women living with HIV in Burkina Faso: The HPV in Africa Research Partnership (HARP) study

被引:8
作者
Devine, Angela [1 ,2 ]
Vahanian, Alice [3 ]
Sawadogo, Bernard [4 ]
Zan, Souleymane [5 ]
Bocoum, Fadima Yaya [6 ]
Kelly, Helen [3 ]
Gilham, Clare [3 ]
Nagot, Nicolas [7 ]
Ong, Jason J. [3 ,8 ]
Legood, Rosa [3 ]
Meda, Nicolas [4 ]
Miners, Alec [3 ]
Mayaud, Philippe [3 ]
机构
[1] Charles Darwin Univ, Global & Trop Hlth Div, Menzies Sch Hlth Res, Darwin, NT, Australia
[2] Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia
[3] London Sch Hyg & Trop Med, London, England
[4] Univ Ouagadougou, Ctr Rech Int Sante, Ouagadougou, Burkina Faso
[5] Ctr Hosp Univ Yalgado Ouedraogo, Ouagadougou, Burkina Faso
[6] Inst Rech Sci Sante, Ouagadougou, Burkina Faso
[7] Univ Montpellier, Pathogenesis & Control Chron Infect, INSERM, Etab Francais Sang, Montpellier, France
[8] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia
基金
欧盟第七框架计划;
关键词
MIDDLE-INCOME COUNTRIES; HUMAN-PAPILLOMAVIRUS; VISUAL INSPECTION; INTRAEPITHELIAL NEOPLASIA; ACETIC-ACID; PERFORMANCE; PREVENTION; LESIONS;
D O I
10.1371/journal.pone.0248832
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Introduction This study estimated the costs and incremental cost per case detected of screening strategies for high-grade cervical intraepithelial neoplasia (CIN2+) in women living with HIV (WLHIV) attending HIV clinics in Burkina Faso. Methods The direct healthcare provider costs of screening tests (visual inspection with acetic acid (VIA), VIA combined visual inspection with Lugol's iodine (VIA/VILI), cytology and a rapid HPV DNA test (careHPV)) and confirmatory tests (colposcopy, directed biopsy and systematic four-quadrant (4Q) biopsy) were collected alongside the HPV in Africa Research Partnership (HARP) study. A model was developed for a hypothetical cohort of 1000 WLHIV using data on CIN2+ prevalence and the sensitivity of the screening tests. Costs are reported in USD (2019). Results The study enrolled 554 WLHIV with median age 36 years (inter-quartile range, 31-41) and CIN2+ prevalence of 5.8%. The average cost per screening test ranged from US$3.2 for VIA to US$24.8 for cytology. Compared to VIA alone, the incremental cost per CIN2+ case detected was US$48 for VIA/VILI and US$814 for careHPV. Despite higher costs, careHPV was more sensitive for CIN2+ cases detected compared to VIA/VILI (97% and 56%, respectively). The cost of colposcopy was US$6.6 per person while directed biopsy was US$33.0 and 4Q biopsy was US$48.0. Conclusion Depending on the willingness to pay for the detection of a case of cervical cancer, decision makers in Burkina Faso can consider a variety of cervical cancer screening strategies for WLHIV. While careHPV is more costly, it has the potential to be cost-effective depending on the willingness to pay threshold. Future research should explore the lifetime costs and benefits of cervical cancer screening to enable comparisons with interventions for other diseases.
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页数:16
相关论文
共 46 条
[1]  
[Anonymous], 2013, WHO guidelines for screening and treatment of precancerous lesions for cervical cancer prevention
[2]  
[Anonymous], HARP STUDY INVESTIGA
[3]  
Assemblee Nationale-Republique du Burkina Faso, 2012, LOI N 041 2010AN LOI
[4]   Performance of Cervical Cancer Screening Techniques in HIV-Infected Women in Uganda [J].
Bansil, Pooja ;
Lim, Jeanette ;
Byamugisha, Josaphat ;
Kumakech, Edward ;
Nakisige, Carol ;
Jeronimo, Jose A. .
JOURNAL OF LOWER GENITAL TRACT DISEASE, 2015, 19 (03) :215-219
[5]  
Bray F., 2018, CA-CANCER J CLIN, V68, P394, DOI DOI 10.3322/caac.21492
[6]  
Campos NG, 2018, JAIDS-J ACQ IMM DEF, V79, P195, DOI [10.1097/QAI.0000000000001778, 10.1097/qai.0000000000001778]
[7]   HPV-FRAME: A consensus statement and quality framework for modelled evaluations of HPV-related cancer control [J].
Canfell, Karen ;
Kim, Jane J. ;
Kulasingam, Shalini ;
Berkhof, Johannes ;
Barnabas, Ruanne ;
Bogaards, Johannes A. ;
Campos, Nicole ;
Jennett, Chloe ;
Sharma, Monisha ;
Simms, Kate T. ;
Smith, Megan A. ;
Velentzis, Louiza S. ;
Brisson, Marc ;
Jit, Mark .
PAPILLOMAVIRUS RESEARCH, 2019, 8
[8]   Introduction of Human Papillomavirus DNA Screening in the World: 15 Years of Experience [J].
Castle, Philip E. ;
de Sanjose, Silvia ;
Qiao, You-Lin ;
Belinson, Jerome L. ;
Lazcano-Ponce, Eduardo ;
Kinney, Walter .
VACCINE, 2012, 30 :F117-F122
[9]  
Centers for Disease Control and Prevention, 1992, MMWR, V41 RR-17
[10]   Comparing Papanicolau smear, visual inspection with acetic acid and human papillomavirus cervical cancer screening methods among HIV-positive women by immune status and antiretroviral therapy [J].
Chung, Michael H. ;
McKenzie, Kevin P. ;
De Vuyst, Hugo ;
Richardson, Barbra A. ;
Rana, Farzana ;
Pamnani, Ritesh ;
Njoroge, Julia W. ;
Nyongesa-Malava, Evans ;
Sakr, Samah R. ;
John-Stewart, Grace C. ;
Mugo, Nelly R. .
AIDS, 2013, 27 (18) :2909-2919