Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions Using a Modular Flow Reactor

被引：44

作者：

Baumann, Marcus ^{[1
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

来源：

SYNLETT | 2010年 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

microreactor; flow chemistry; pyrrolidine; dipolar cycloaddition; solid-supported reagents; MULTISTEP SYNTHESIS; ORGANIC-SYNTHESIS; MICROREACTOR; CHEMISTRY;

D O I：

10.1055/s-0029-1219344

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The generation and subsequent use of unstabilised azomethine ylides in dipolar cycloaddition reactions within a flow microreactor is demonstrated. The 3-nitropyrrolidines produced were furthermore subjected to chemoselective hydrogenation reactions using the H-Cube (R) system. To ensure product purities in excess of 90-95%, immobilised scavengers were successfully employed.

引用

页码：749 / 752

页数：4

共 44 条

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