Differential regulation of tyrosine hydroxylase in cuticular melanization and innate immunity in the silkworm Bombyx mori

被引：31

作者：

Lee, Kwang Sik ^{[1
]}

Kim, Bo Yeon ^{[1
]}

Jin, Byung Rae ^{[1
]}

机构：

[1] Dong A Univ, Coll Nat Resources & Life Sci, Busan 604714, South Korea

来源：

JOURNAL OF ASIA-PACIFIC ENTOMOLOGY | 2015年 / 18卷 / 04期

关键词：

Bombyx mori; Cuticular melanization; Development; Innate immunity; Tyrosine hydroxylase; N-ACETYLTRANSFERASE; DOPA DECARBOXYLASE; MELANIN-SYNTHESIS; FAT-BODY; EXPRESSION; INSECT; PHENOLOXIDASE; METAMORPHOSIS; METABOLISM; CLONING;

D O I：

10.1016/j.aspen.2015.09.008

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Insect cuticular melanization is a defense mechanism involving the prophenoloxidase (proPO)-activating system. Here, we showed the differential regulation of tyrosine hydroxylase in silkworm (Bombyx mori) pupae. B. mori tyrosine hydroxylase (BmTH) was expressed in the epidermis during development or in the fat body during infection, which indicates that the differential expression of BmTH is responsible for cuticular melanization or innate immunity. The melanin of the silkworm pupal cuticle formed a melanization complex with Beauveria bassiana and this effect showed an antifungal activity, indicating that melanin in silkworm pupal cuticle plays a role in the defense against fungal pathogens. Finally, we found that the differential expression of BmTH is involved in pupal cuticular melanization and adult pigmentation as well as the innate immunity of silkworms, demonstrating a differential regulation of BmTH in a tissue-specific manner. (C) 2015 Korean Society of Applied Entomology, Taiwan Entomological Society and Malaysian Plant Protection Society. Published by Elsevier B.V. All rights reserved.

引用

页码：765 / 770

页数：6

共 27 条

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