Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats

被引：18

作者：

Janssen, PL ^{[1
]}

O'Halloran, KD ^{[1
]}

Pizarro, J ^{[1
]}

Dwinell, MR ^{[1
]}

Bisgard, GE ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Vet Med, Dept Comparat Biosci, Madison, WI 53706 USA

来源：

RESPIRATION PHYSIOLOGY | 1998年 / 111卷 / 01期

关键词：

carotid body; sustained hypoxia; dopamine; control of breathing; hypoxia; sustained; ventilatory acclimatization; mammals; goat; mediators; pharmacological agents; domperidone;

D O I：

10.1016/S0034-5687(97)00060-1

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Ventilatory acclimatization to sustained hypoxia (VASH) is the time-dependent increase in Ventilation that occurs during prolonged exposure to hypoxia. We tested the hypothesis that carotid body (CB) dopaminergic mechanisms are down-regulated during VASH, which would allow CB afferent discharge and ventilation to increase beyond the initial response to hypoxia. Domperidone (DOM; 1.0 mg.kg(-1)) was administered intravenously to block CB dopamine (DA) receptors after VASH was complete in awake goats. DOM caused a significant augmentation of the ventilatory response to hypoxia in acclimatized goats, failing to support the hypothesis. We conclude that inhibitory CB dopaminergic function is not significantly reduced following prolonged hypoxia, and that down-regulation of CB dopaminergic mechanisms may not be involved in VASH in the goat. (C) 1998 Elsevier Science B.V.

引用

页码：25 / 32

页数：8

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