Identification and characterization of a supraclavicular brown adipose tissue in mice

被引：29

作者：

Mo, Qianxing ^{[1
,2
]}

Salley, Jordan ^{[3
]}

Roshan, Tony ^{[3
]}

Baer, Lisa A. ^{[4
]}

May, Francis J. ^{[4
]}

Jaehnig, Eric J. ^{[5
]}

Lehnig, Adam C. ^{[4
]}

Guo, Xin ^{[3
]}

Tong, Qiang ^{[3
]}

Nuotio-Antar, Alli M. ^{[3
]}

Shamsi, Farnaz ^{[6
]}

Tseng, Yu-Hua ^{[6
]}

Stanford, Kristin I. ^{[4
]}

Chen, Miao-Hsueh ^{[3
]}

机构：

[1] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[2] Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA

[3] Baylor Coll Med, Childrens Nutr Res Ctr, Dept Pediat, USDA ARS, Houston, TX 77030 USA

[4] Ohio State Univ, Dept Physiol & Cell Biol, Wexner Med Ctr, Dorothy M Davis Heart & Lung Res Inst, Columbus, OH 43210 USA

[5] Rice Univ, Dept Bioengn, Houston, TX USA

[6] Harvard Med Sch, Joslin Diabet Ctr, Boston, MA USA

来源：

JCI INSIGHT | 2017年 / 2卷 / 11期

关键词：

BEIGE ADIPOCYTES; GENE-EXPRESSION; ADULT HUMANS; FUNCTIONAL-CHARACTERIZATION; GLUCOSE-HOMEOSTASIS; INSULIN SENSITIVITY; COLD-EXPOSURE; WHITE; FAT; DISTINCT;

D O I：

10.1172/jci.insight.93166

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A fundamental challenge to our understanding of brown adipose tissue (BAT) is the lack of an animal model that faithfully represents human BAT. Such a model is essential for direct assessment of the function and therapeutic potential of BAT depots in humans. In human adults, most of the thermoactive BAT depots are located in the supraclavicular region of the neck, while mouse studies focus on depots located in the interscapular region of the torso. We recently discovered BAT depots that are located in a region analogous to that of human supraclavicular BAT (scBAT). Here, we report that the mouse scBAT depot has morphological characteristics of classical BAT, possesses the potential for high thermogenic activity, and expresses a gene signature that is similar to that of human scBAT. Taken together, our studies reveal a mouse BAT depot that represents human BAT and provides a unique tool for developing new translatable approaches for utilizing human scBAT.

引用

页数：14

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