Prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations

被引：18

作者：

Miyata, Tatsunori ^{[1
]}

Yamashita, Yo-ichi ^{[1
]}

Yamao, Takanobu ^{[1
]}

Umezaki, Naoki ^{[1
]}

Tsukamoto, Masayo ^{[1
]}

Kitano, Yuki ^{[1
]}

Yamamura, Kensuke ^{[1
]}

Arima, Kota ^{[1
]}

Kaida, Takayoshi ^{[1
]}

Nakagawa, Shigeki ^{[1
]}

Imai, Katsunori ^{[1
]}

Hashimoto, Daisuke ^{[1
]}

Chikamoto, Akira ^{[1
]}

Ishiko, Takatoshi ^{[1
]}

Baba, Hideo ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Life Sci, Dept Surg Gastroenterol, Chuo Ku, 1-1-1 Honjyo, Kumamoto 8600811, Japan

来源：

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 22卷 / 03期

基金：

日本学术振兴会;

关键词：

ICC; Postoperative complication; Prognosis; Lymph node dissection; LONG-TERM SURVIVAL; SQUAMOUS-CELL CARCINOMA; LYMPH-NODE DISSECTION; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; MORTALITY-RATES; RESECTION; LIVER; OUTCOMES; SURGERY;

D O I：

10.1007/s10147-017-1099-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background The postoperative complication is one of an indicator of poor prognosis in patients with several gastro-enterological cancers after curative operations. We, herein, examined prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations. Methods We retrospectively analyzed 60 patients with intrahepatic cholangiocarcinoma who underwent primary curative operations from June 2002 to February 2016. Prognostic impacts of postoperative complications were analyzed using log-rank test and Cox proportional hazard model. Results Postoperative complications (Clavien-Dindo classification grade 3 or more) occurred in 13 patients (21.7%). Overall survival of patients without postoperative complications was significantly better than that of patients with postoperative complications (p = 0.025). Postoperative complications are independent prognostic factor of overall survival (hazard ratio 3.02; p = 0.030). In addition, bile duct resection and reconstruction (Odds ratio 59.1; p = 0.002) and hepatitis C virus antibody positive (Odds ratio 7.14; p= 0.022), and lymph node dissection (Odds ratio 6.28; p = 0.040) were independent predictors of postoperative complications. Conclusion Postoperative complications may be an independent predictor of poorer survival in patients with intrahepatic cholangiocarcinoma after curative operations. Lymph node dissection and bile duct resection and reconstruction were risk factors for postoperative complications, therefore we should pay attentions to perform lymph node dissections, bile duct resection and reconstruction in patients with intrahepatic cholangiocarcinoma.

引用

页码：526 / 532

页数：7

共 30 条

[1] Prognostic Impact of Preoperative Lymph Node Enlargement in Intrahepatic Cholangiocarcinoma: A Multi-Institutional Study by the Kyushu Study Group of Liver Surgery [J].