Novel "Elements" of Immune Suppression within the Tumor Microenvironment

被引：54

作者：

Gurusamy, Devikala ^{[1
,2
]}

Clever, David ^{[3
]}

Eil, Robert ^{[4
]}

Restifo, Nicholas P. ^{[1
,2
]}

机构：

[1] NCI, Surg Branch, NIH, Bldg 10, Bethesda, MD 20892 USA

[2] NCI, Ctr Cell Based Therapy, NIH, Bethesda, MD 20892 USA

[3] Ohio State Univ, Coll Med, Med Scientist Training Program, Columbus, OH 43210 USA

[4] Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA

来源：

CANCER IMMUNOLOGY RESEARCH | 2017年 / 5卷 / 06期

关键词：

REGULATORY T-CELLS; ACQUIRED-RESISTANCE; PROGNOSTIC VALUE; DENDRITIC CELLS; KV1.3; CHANNELS; HYPOXIA; CANCER; ACTIVATION; IMMUNOTHERAPY; LYMPHOCYTES;

D O I：

10.1158/2326-6066.CIR-17-0117

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adaptive evolution has prompted immune cells to use a wide variety of inhibitory signals, many of which are usurped by tumor cells to evade immune surveillance. Although tumor immunologists often focus on genes and proteins as mediators of immune function, here we highlight two elements from the periodic table-oxygen and potassium-that suppress the immune system in previously unappreciated ways. While both are key to the maintenance of T-cell function and tissue homeostasis, they are exploited by tumors to suppress immuno-surveillance and promote metastatic spread. We discuss the temporal and spatial roles of these elements within the tumor microenvironment and explore possible therapeutic interventions for effective and promising anticancer therapies. (C)2017 AACR.

引用

页码：426 / 433

页数：8

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