Cerebral blood flow changes during aging process and in cognitive disorders: A review

被引：52

作者：

Mokhber, Naghmeh ^{[1
,2
]}

Shariatzadeh, Aidin ^{[3
]}

Avan, Abolfazl ^{[4
]}

Saber, Hamidreza ^{[5
]}

Babaei, Golnaz Shojaeian ^{[4
]}

Chaimowitz, Gary ^{[6
]}

Azarpazhooh, M. Reza ^{[3
,7
]}

机构：

[1] Western Univ, Dept Psychiat, London, ON, Canada

[2] Mashhad Univ Med Sci, Dept Psychiat & Neuropsychiat, Mashhad, Razavi Khorasan, Iran

[3] Robarts Res Inst, Stroke Prevent & Atherosclerosis Res Ctr, London, ON, Canada

[4] Mashhad Univ Med Sci, Dept Publ Hlth, Mashhad, Razavi Khorasan, Iran

[5] Wayne State Univ, Sch Med, Dept Neurol, Detroit, MI 48201 USA

[6] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

[7] Western Univ, Dept Clin Neurol Sci, London, ON, Canada

来源：

NEURORADIOLOGY JOURNAL | 2021年 / 34卷 / 04期

关键词：

Cerebrovascular circulation; neurovascular coupling; functional imaging; cognitive disorders; neuronal loss; aging;

D O I：

10.1177/19714009211002778

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

We aimed to summarize the available evidence on cerebral blood flow (CBF) changes in normal aging and common cognitive disorders. We searched PubMed for studies on CBF changes in normal aging and cognitive disorders up to 1 January 2019. We summarized the milestones in the history of CBF assessment and reviewed the current evidence on the association between CBF and cognitive changes in normal aging, vascular cognitive impairment (VCI) and Alzheimer's disease (AD). There is promising evidence regarding the utility of CBF studies in cognition research. Age-related CBF changes could be related to a progressive neuronal loss or diminished activity and synaptic density of neurons in the brain. While a similar cause or outcome theory applies to VCI and AD, it is possible that CBF reduction might precede cognitive decline. Despite the diversity of CBF research findings, its measurement could help early detection of cognitive disorders and also understanding their underlying etiology.

引用

页码：300 / 307

页数：8

共 90 条

[1] NON-INVASIVE TRANSCRANIAL DOPPLER ULTRASOUND RECORDING OF FLOW VELOCITY IN BASAL CEREBRAL-ARTERIES [J].

AASLID, R ;

MARKWALDER, TM ;

NORNES, H .

JOURNAL OF NEUROSURGERY, 1982, 57 (06) :769-774

[2] Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes [J].

Al-Bachari, Sarah ;

Vidyasagar, Rishma ;

Emsley, Hedley C. A. ;

Parkes, Laura M. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2017, 37 (10) :3409-3421

[3] Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI [J].

Alexopoulos, Panagiotis ;

Sorg, Christian ;

Foerschler, Annette ;

Grimmer, Timo ;

Skokou, Maria ;

Wohlschlaeger, Afra ;

Perneczky, Robert ;

Zimmer, Claus ;

Kurz, Alexander ;

Preibisch, Christine .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2012, 262 (01) :69-77

[4]

Alsop DC, 2000, ANN NEUROL, V47, P93, DOI 10.1002/1531-8249(200001)47:1<93::AID-ANA15>3.0.CO

[5]

2-8

[6] Regional Cerebral Blood Flow Single Photon Emission Computed Tomography for detection of Frontotemporal dementia in people with suspected dementia [J].

Archer, Hilary A. ;

Smailagic, Nadja ;

John, Christeena ;

Holmes, Robin B. ;

Takwoingi, Yemisi ;

Coulthard, Elizabeth J. ;

Cullum, Sarah .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2015, (06)

[7] Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer's disease [J].

Benedictus, Marije R. ;

Leeuwis, Annebet E. ;

Binnewijzend, Maja A. A. ;

Kuijer, Joost P. A. ;

Scheltens, Philip ;

Barkhof, Frederik ;

van der Flier, Wiesje M. ;

Prins, Niels D. .

EUROPEAN RADIOLOGY, 2017, 27 (03) :1169-1175

[8] High total cerebral blood flow is associated with a decrease of white matter lesions [J].

Bisschops, RHC ;

van der Graaf, Y ;

Mali, WPTM ;

van der Grond, J .

JOURNAL OF NEUROLOGY, 2004, 251 (12) :1481-1485

[9] Blood pressure gradients in cerebral arteries: a clue to pathogenesis of cerebral small vessel disease [J].

Blanco, Pablo J. ;

Mueller, Lucas O. ;

Spcene, J. David .

STROKE AND VASCULAR NEUROLOGY, 2017, 2 (03) :108-117

[10] High Prevalence of Cerebral Microbleeds at 7Tesla MRI in Patients with Early Alzheimer's Disease [J].

Brundel, Manon ;

Heringa, Sophie M. ;

de Bresser, Jeroen ;

Koek, Huiberdina L. ;

Zwanenburg, Jaco J. M. ;

Kappelle, L. Jaap ;

Luijten, Peter R. ;

Biessels, Geert Jan .

JOURNAL OF ALZHEIMERS DISEASE, 2012, 31 (02) :259-263

← 1 2 3 4 5 6 7 8 9 →