Factors influencing the immunogenicity of influenza vaccines

被引：20

作者：

Wen, Simin ^{[1
]}

Wu, Zhengyu ^{[1
]}

Zhong, Shuyi ^{[1
]}

Li, Mao ^{[1
]}

Shu, Yuelong ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Guangzhou 510275, Guangdong, Peoples R China

[2] Chinese Ctr Dis Prevent & Control, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2021年 / 17卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Influenza; vaccine; immunogenicity; immune response; T-CELL RESPONSES; ADULTS; 18-64; YEARS; A H1N1 VACCINE; IMMUNE-RESPONSE; ANTIBODY-RESPONSES; HEALTHY-ADULTS; B-CELL; PROTECTIVE EFFICACY; VIRUS INFECTION; SEX-DIFFERENCES;

D O I：

10.1080/21645515.2021.1875761

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Annual vaccination is the best prevention of influenza. However, the immunogenicity of influenza vaccines varies among different populations. It is important to fully identify the factors that may affect the immunogenicity of the vaccines to provide best protection for vaccine recipients. This paper reviews the factors that may influence the immunogenicity of influenza vaccines from the aspects of vaccine factors, adjuvants, individual factors, repeated vaccination, and genetic factors. The confirmed or hypothesized molecular mechanisms of these factors have also been briefly summarized.

引用

页码：2706 / 2718

页数：13

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