Hepatitis B virus infection and associated risk factors among medical students in eastern Ethiopia

被引:10
作者
Tesfa, Tewodros [1 ]
Hawulte, Behailu [2 ]
Tolera, Abebe [3 ]
Abate, Degu [1 ]
机构
[1] Haramaya Univ, Coll Hlth & Med Sci, Dept Med Lab Sci, Harar, Ethiopia
[2] Haramaya Univ, Coll Hlth & Med Sci, Sch Publ Hlth, Publ Hlth & Policy Unit, Harar, Ethiopia
[3] Haramaya Univ, Coll Hlth & Med Sci, Sch Publ Hlth, Epidemiol & Biostat Unit, Harar, Ethiopia
来源
PLOS ONE | 2021年 / 16卷 / 02期
关键词
HEALTH-CARE WORKERS; OCCUPATIONAL-SAFETY; WASTE MANAGEMENT; PREVALENCE; HOSPITALS; KNOWLEDGE; SEROPREVALENCE; BURDEN;
D O I
10.1371/journal.pone.0247267
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Hepatitis B virus (HBV) is a highly contagious pathogen that has become a severe public health problem and a major cause of morbidity and mortality, particularly in developing countries. Medical students are at high occupational risk during their training. However, no facility-based studies were found among medical students in eastern Ethiopia. Thus, this study aimed to investigate the seroprevalence of Hepatitis B Virus and associated factors among medical students in eastern Ethiopia. Methods A facility-based cross-sectional study was conducted among 407 randomly selected medical students from March to June 2018. A pretested and structured questionnaire was used to collect data on socio-demographic characteristics and other risk factors. A 5ml blood was collected, and the serum was analyzed for Hepatitis B surface antigen (HBsAg) using the Instant Hepatitis B surface antigen kit. Data were entered using Epidata version 3.1 and analyzed using SPSS statistical packages version 22. Outcome and explanatory variables were described using descriptive summary measures. Binary and multivariable logistic regression was conducted at 95% CI and an association at P-value < 0.05 was declared statistically significant. Results The seroprevalence of hepatitis B virus surface antigen was 11.5% (95%CI = 8.6, 14.7). Poor knowledge of universal precaution guideline (AOR = 2.58; 95% CI = [1.35-4.93]), history of needle stick injury (AOR = 2.11; 95% CI = [1.07-4.18]) and never been vaccinated for HBV (AOR = 2.34; 95% CI = [1.17-4.69]) were found statistically significantly associated with HBsAg positivity after multivariate analysis. Conclusion Hepatitis B virus infection rate is high among health care trainees in eastern Ethiopia. Improvement at health care practice centers safety through training on universal precaution guidelines, and scaling up HBV vaccination is mandatory.
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页数:11
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