Modelling the interactions of CCR2 antagonists with their receptor.

被引:0
|
作者
Blaney, FE [1 ]
机构
[1] GlaxoSmithKline, Analyt & Struct Studies, Harlow, Essex, England
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
068-COMP
引用
收藏
页码:U906 / U906
页数:1
相关论文
共 50 条
  • [21] Substituted dipiperidine alcohols as potent CCR2 antagonists
    Xia, Mingde
    Hou, Cuifen
    DeMong, Duane
    Pollack, Scott
    Pan, Meng
    Brackley, James
    Singer, Monica
    Matheis, Michele
    Cavender, Druie
    Wachter, Michael
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (12) : 3562 - 3564
  • [22] In vivo activity of an azole series of CCR2 antagonists
    Smethurst, Chris A.
    Bevan, Nicola
    Brooks, Carl
    Emmons, Amanda
    Gough, Peter J.
    Mookherjee, Claudette
    Moores, Kitty
    Peace, Simon
    Philp, Joanne
    Piercy, Val
    Watson, Steve P.
    Zippoli, Mara
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (23) : 7252 - 7255
  • [23] Longer Receptor Residence Times Improve the Effectiveness of CCR2 Antagonists in the Prevention of Atherosclerosis
    Bot, Ilze
    Zacarias, Natalia V. Ortiz
    de Vries, Henk
    van Santbrink, Peter J.
    van der Velden, Daniel
    Kuiper, Johan
    Stamos, Dean
    Ijzerman, Adriaan P.
    Heitman, Laura H.
    CIRCULATION, 2015, 132
  • [24] The CCR2 receptor as a therapeutic target
    Feria, M
    Díaz-González, F
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2006, 16 (01) : 49 - 57
  • [25] Identification of highly specific nonpeptide antagonists of the CCR1 receptor.
    Horuk, R
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U62 - U62
  • [26] γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists
    Cherney, Robert J.
    Mo, Ruowei
    Meyer, Dayton T.
    Voss, Matthew E.
    Yang, Michael G.
    Santella, Joseph B., III
    Duncia, John V.
    Lo, Yvonne C.
    Yang, Gengjie
    Miller, Persymphonie B.
    Scherle, Peggy A.
    Zhao, Qihong
    Mandlekar, Sandhya
    Cvijic, Mary Ellen
    Barrish, Joel C.
    Decicco, Carl P.
    Carter, Percy H.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (08) : 2425 - 2430
  • [27] Sulfone-containing trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists
    Cherney, Robert J.
    Mo, Ruowei
    Meyer, Dayton T.
    Lo, Yvonne C.
    Yang, Gengjie
    Miller, Persymphonie B.
    Scherle, Peggy A.
    Zhao, Qihong
    Mandlekar, Sandhya
    Cvijic, Mary Ellen
    Tebben, Andrew J.
    Carter, Percy H.
    Barrish, Joel C.
    Decicco, Carl P.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [28] Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists
    Cherney, Robert J.
    Moa, Ruowei
    Yang, Michael G.
    Xiao, Zili
    Zhao, Qihong
    Mandlekar, Sandhya
    Cvijic, Mary Ellen
    Charo, Israel F.
    Barrish, Joel C.
    Decicco, Carl P.
    Carter, Percy H.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (07) : 1843 - 1845
  • [29] Rational design of CCR2 antagonists: a survey of computational studies
    Sobhia, Masilamani Elizabeth
    Singh, Rajesh
    Kare, Pavan
    Chavan, Swapnil
    EXPERT OPINION ON DRUG DISCOVERY, 2010, 5 (06) : 543 - 557
  • [30] CCR2 chemokine receptor and AIDS progression
    Smith, MW
    Carrington, M
    Winkler, C
    Lomb, D
    Dean, M
    Huttley, G
    OBrien, SJ
    NATURE MEDICINE, 1997, 3 (10) : 1052 - 1053