HLA mismatching as a strategy to reduce relapse after alternative donor transplantation

被引:47
作者
Fleischhauer, Katharina [1 ,2 ]
Beelen, Dietrich W. [3 ]
机构
[1] Univ Hosp Essen, Inst Expt Cellular Therapy, Hufelandstr 55, D-45122 Essen, Germany
[2] German Canc Consortium DKTK, Heidelberg, Germany
[3] Univ Hosp Essen, West German Canc Ctr, Dept Bone Marrow Transplantat, D-45122 Essen, Germany
关键词
HLA mismatch; Alloreactivity; Graft-versus-leukemia; MUD HSCT; Haploidentical HSCT; Umbilical cord blood HSCT; HEMATOPOIETIC STEM-CELL; ACUTE MYELOID-LEUKEMIA; GRAFT-VERSUS-LEUKEMIA; HUMAN-LEUKOCYTE ANTIGEN; CORD-BLOOD TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; HOST-DISEASE PROPHYLAXIS; MINIMAL RESIDUAL DISEASE; RISK ACUTE-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA;
D O I
10.1053/j.seminhematol.2016.01.010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Human leukocyte antigen (HLA) mismatches are targets of alloreactive T cells, mediators of graft-versus-leukemia (GvL) and graft-versus-host disease (GvHD) after alternative donor transplantation. Exploitation of HLA mismatching in order to reduce relapse is hampered by necessary interventions aimed at controlling GvHD on the one hand, and by the possibility of immune escape through selective loss of mismatched HLA in relapsing leukemia on the other. Retrospective studies reporting the impact of HLA mismatches on post-transplant relapse need to be interpreted with caution, due to many confounding factors, including disease and use of T-cell depletion, and to be constantly updated to the rapidly changing clinical protocols. Current evidence suggests similar relapse rates for 8/8, 7/8 HLA-matched unrelated, T-cell-replete haploidentical and umbilical cord blood transplantation; however, investigations of locus-specific effects are still scarce in the latter two settings. In unrelated transplantation, a specific role for mismatches at HLA-C and HLA-DPB1, and therein of permissive mismatches defined on the basis of T-cell alloreactivity and/or expression levels, in reducing relapse has been demonstrated in independent studies. This observation suggests new approaches to utilize HLA matching in unrelated donor searches, and the need for further research in the field. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:57 / 64
页数:8
相关论文
共 108 条
  • [1] Post-Transplant High-Dose Cyclophosphamide for the Prevention of Graft-versus-Host Disease
    Al-Homsi, Ahmad Samer
    Roy, Tara S.
    Cole, Kelli
    Feng, Yuxin
    Duffner, Ulrich
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (04) : 604 - 611
  • [2] Allo-HLA reactivity of virus-specific memory T cells is common
    Amir, Avital L.
    D'Orsogna, Lloyd J. A.
    Roelen, Dave L.
    van Loenen, Marleen M.
    Hagedoorn, Renate S.
    de Boer, Renate
    van der Hoorn, Menno A. W. G.
    Kester, Michel G. D.
    Doxiadis, Ilias I. N.
    Falkenburg, J. H. Frederik
    Claas, Frans H. J.
    Heemskerk, Mirjam H. M.
    [J]. BLOOD, 2010, 115 (15) : 3146 - 3157
  • [3] T-cell allorecognition: a case of mistaken identity or deja vu?
    Archbold, Julia K.
    Macdonald, Whitney A.
    Burrows, Scott R.
    Rossjohn, Jamie
    McCluskey, James
    [J]. TRENDS IN IMMUNOLOGY, 2008, 29 (05) : 220 - 226
  • [4] Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype
    Aversa, F
    Tabilio, A
    Velardi, A
    Cunningham, I
    Terenzi, A
    Falzetti, F
    Ruggeri, L
    Barbabietola, G
    Aristei, C
    Latini, P
    Reisner, Y
    Martelli, MF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (17) : 1186 - 1193
  • [5] A closer look at permissive HLA mismatch
    Bacigalupo, Andrea
    [J]. BLOOD, 2013, 122 (22) : 3555 - 3556
  • [6] T-Cell-Replete HLA-Haploidentical Hematopoietic Transplantation for Hematologic Malignancies Using Post-Transplantation Cyclophosphamide Results in Outcomes Equivalent to Those of Contemporaneous HLA-Matched Related and Unrelated Donor Transplantation
    Bashey, Asad
    Zhang, Xu
    Sizemore, Connie A.
    Manion, Karen
    Brown, Stacey
    Holland, H. Kent
    Morris, Lawrence E.
    Solomon, Scott R.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (10) : 1310 - 1316
  • [7] Haploidentical T Cell-Replete Transplantation with Post-Transplantation Cyclophosphamide for Patients in or above the Sixth Decade of Age Compared with Allogeneic Hematopoietic Stem Cell Transplantation from an Human Leukocyte Antigen-Matched Related or Unrelated Donor
    Blaise, Didier
    Fuerst, Sabine
    Crocchiolo, Roberto
    El-Cheikh, Jean
    Granata, Angela
    Harbi, Samia
    Bouabdallah, Reda
    Devillier, Raynier
    Bramanti, Stephania
    Lemarie, Claude
    Picard, Christophe
    Chabannon, Christian
    Weiller, Pierre-Jean
    Faucher, Catherine
    Mohty, Bilal
    Vey, Norbert
    Castagna, Luca
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2016, 22 (01) : 119 - 124
  • [8] Reduced-intensity conditioning versus standard conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: a prospective, open-label randomised phase 3 trial
    Bornhaeuser, Martin
    Kienast, Joachim
    Trenschel, Rudolf
    Burchert, Andreas
    Hegenbart, Ute
    Stadler, Michael
    Baurmann, Herrad
    Schaefer-Eckart, Kerstin
    Holler, Ernst
    Kroeger, Nicolaus
    Schmid, Christoph
    Einsele, Herrmann
    Kiehl, Michael G.
    Hiddemann, Wolfgang
    Schwerdtfeger, Rainer
    Buchholz, Stefanie
    Dreger, Peter
    Neubauer, Andreas
    Berdel, Wolfgang E.
    Ehninger, Gerhard
    Beelen, Dietrich W.
    Schetelig, Johannes
    Stelljes, Matthias
    [J]. LANCET ONCOLOGY, 2012, 13 (10) : 1035 - 1044
  • [9] Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
    Byrd, John C.
    Furman, Richard R.
    Coutre, Steven E.
    Flinn, Ian W.
    Burger, Jan A.
    Blum, Kristie A.
    Grant, Barbara
    Sharman, Jeff P.
    Coleman, Morton
    Wierda, William G.
    Jones, Jeffrey A.
    Zhao, Weiqiang
    Heerema, Nyla A.
    Johnson, Amy J.
    Sukbuntherng, Juthamas
    Chang, Betty Y.
    Clow, Fong
    Hedrick, Eric
    Buggy, Joseph J.
    James, Danelle F.
    O'Brien, Susan
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (01) : 32 - 42
  • [10] Naive subset develops the most important alloreactive response among human CD4+ T lymphocytes in Human Leukocyte Antigen-identical related setting
    Cherel, Mathilde
    Choufi, Bachra
    Trauet, Jacques
    Cracco, Pascale
    Dessaint, Jean-Paul
    Yakoub-Agha, Ibrahim
    Labalette, Myriam
    [J]. EUROPEAN JOURNAL OF HAEMATOLOGY, 2014, 92 (06) : 491 - 496