Increased S-nitrosothiols are associated with spinal cord injury in multiple sclerosis

被引：8

作者：

Fominykh, Vera ^{[1
]}

Onufriev, Mikhail V. ^{[1
]}

Vorobyeva, Anna ^{[2
]}

Brylev, Lev ^{[1
]}

Yakovlev, Alexander A. ^{[1
]}

Zakharova, Maria N. ^{[2
]}

Gulyaeva, Natalia V. ^{[1
]}

机构：

[1] RAS, Inst Higher Nervous Act & Neurophysiol, Dept Funct Biochem Nervous Syst, Butlerov St 5A, Moscow 117485, Russia

[2] Russian Acad Med Sci, Res Ctr Neurol, Neuroinfect Dept, Moscow, Russia

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2016年 / 28卷

关键词：

Multiple sclerosis; Nitric oxide; S-nitrosothiols; Spinal cord; NITRIC-OXIDE SYNTHASE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; BLOOD-FLOW REGULATION; CEREBROSPINAL-FLUID; OXIDATIVE STRESS; EXPRESSION; NITROTYROSINE; DEMYELINATION; GLUTATHIONE; NITROSOCYSTEINE;

D O I：

10.1016/j.jocn.2015.09.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis (MS) is an immune-mediated disorder associated with inflammation, demyelination and axonal damage. In search of potential biomarkers of spinal cord lesions in MS related to nitric oxide metabolites, we measured total nitrite and nitrate levels, and protein-bound nitrotyrosine and S-nitrosothiol concentrations in the serum of MS patients at different stages of the disease. Sixty-eight patients and 36 healthy volunteers were included in the study. Total nitrite and nitrate levels were augmented in relapsing-remitting MS, while increased S-nitrosothiol concentrations were found both in relapsing-remitting and secondary-progressive MS. Further analysis demonstrated that S-nitrosothiol levels were selectively increased in patients with spinal cord injury. The data suggest that high S-nitrosothiol concentration may be a potential serum biomarker for spinal cord injury in MS. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：38 / 42

页数：5

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