Synthesis and biological evaluation of novel spiro 6-methoxytetralin-1,3′-pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice

被引：27

作者：

Hossain, Ugir ^{[2
]}

Sharma, Arun K. ^{[2
]}

Ghosh, Sulekha ^{[3
]}

Bhattacharya, Sudin ^{[1
]}

机构：

[1] Chittaranjan Natl Canc Inst, Dept Canc Chemoprevent, Kolkata 700026, W Bengal, India

[2] Penn State Coll Med, Dept Pharmacol, Chem Carcinogenesis & Chemoprevent Program, Penn State Hershey Canc Inst, Hershey, PA 17033 USA

[3] Burdwan Med Coll, Burdwan 713104, W Bengal, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 08期

关键词：

Organoselenocyanate; Cadmium; Hepatoprotective; Oxidative stress; INDUCED LIPID-PEROXIDATION; SUPEROXIDE-DISMUTASE; DIPHENYL DISELENIDE; TRANSITION-METALS; ALPHA-TOCOPHEROL; SELENIUM; TOXICITY; RATS; GLUTATHIONE; LIVER;

D O I：

10.1016/j.ejmech.2010.04.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3'-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium- (Cd) induced toxicity in Swiss Albino mice. All the compounds (6a-d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities, e.g., alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds, 6d being the most active one (6d > 6c > 6b > 6a). (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：3265 / 3273

页数：9

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