Lipase-catalysed regioselective acylations in combination with regioselective glycosylations as a strategy for the synthesis of oligosaccharides: Synthesis of a series of fucosyllactose building blocks

被引：6

作者：

Rencurosi, A

Poletti, L

Russo, G

Lay, L

机构：

[1] Univ Milan, Ctr Interdisciplinare Studi Biomol & Applicaz Ind, CISI, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[2] CNR, Ist Sci & Tecnol Mol, I-20133 Milan, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 09期

关键词：

oligosaccharides; fucosyllactose; glycosylation; lipase acylation;

D O I：

10.1002/ejoc.200200425

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A family of five regioisomenc protected fucosyllactoses has been synthesised in only 14 overall steps from the easily available benzyllactoside. The adopted strategy combines enzymatic regioselective protection, introduction of ortho-gonal protecting groups and regioselective glycosylations on partially unprotected lactosidic acceptors.

引用

页码：1672 / 1680

页数：9

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