Engulfment: Ingestion and migration with Rac, Rho and TRIO

被引：25
作者：
Henson, PM [1 ]
机构：
[1] Natl Jewish Med & Res Ctr, Denver, CO 80206 USA
来源：
CURRENT BIOLOGY | 2005年 / 15卷 / 01期
关键词：
D O I：
10.1016/j.cub.2004.12.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Apoptotic cells are removed from tissues by uptake mechanisms that depend on the GTPase Rac (CED-10 in C. elegans), which is activated by DOCK180/CED-5 in a trimolecular complex with ELMO/CED-12 and CrkII/CED-2. A study now identifies upstream components of this pathway in both worms and mammalian cells involving yet another GTPase, RhoG/MIG-2, and its activator TRIO/UNC-73.
引用
收藏
页码：R29 / R30
页数：2
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