Modulation of signal transduction in cancer cells by phytosterols

被引:40
作者
Bradford, Peter G. [1 ]
Awad, Atif B. [2 ]
机构
[1] SUNY Buffalo, Dept Pharmacol & Toxicol, Sch Med & Biomed Sci, Buffalo, NY 14214 USA
[2] SUNY Buffalo, Dept Exercise & Nutr Sci, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14214 USA
关键词
phytosterols; cancer chemoprevention; ceramide; liver X receptor; apoptosis; LIVER-X-RECEPTORS; BETA-SITOSTEROL; PLANT STEROLS; HUMAN BREAST; ALKALINE SPHINGOMYELINASE; LXR-ALPHA; IN-VITRO; APOPTOSIS; CHOLESTEROL; PROLIFERATION;
D O I
10.1002/biof.97
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phytosterols are biofactors found enriched in plant foods such as seeds, grains, and legumes. Their dietary consumption is associated with numerous health benefits. Epidemiologic and experimental animal studies indicate that phytosterols are cancer chemopreventive agents particularly against cancers of the colon, breast, and prostate. Phytosterols impede oncogenesis and prevent cancer cell proliferation and survival. The molecular mechanisms underlying these beneficial actions involve effects on signal transduction processes which regulate cell growth and apoptosis. Phytosterols increase sphingomyelin turnover, ceramide formation, and liver X receptor activation. In concert, these actions slow cell cycle progression, inhibit cell proliferation, and activate caspase cascades and apoptosis in cancer cells. (C) 2010 International Union of Biochemistry and Molecular Biology, Inc. Volume 36, Number 4, July/August 2010, Pages 241-247 . E-mail: pgb@buffalo.edu
引用
收藏
页码:241 / 247
页数:7
相关论文
共 73 条
  • [1] [Anonymous], 2007, Cancer trends progress report - 2007 update
  • [2] [Anonymous], 2007, FOOD NUTR PHYS ACT P
  • [3] ARORA R, 2010, HERBAL MED CANC CHEM, P3
  • [4] β-sitosterol activates Fas signaling in human breast cancer cells
    Awad, A. B.
    Chinnam, M.
    Fink, C. S.
    Bradford, P. G.
    [J]. PHYTOMEDICINE, 2007, 14 (11) : 747 - 754
  • [5] Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells
    Awad, AB
    Williams, H
    Fink, CS
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2001, 40 (02): : 157 - 164
  • [6] Awad AB, 1996, ANTICANCER RES, V16, P2797
  • [7] β-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells
    Awad, AB
    Fink, CS
    Trautwein, EA
    Ntanios, FY
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2005, 16 (11) : 650 - 655
  • [8] Peanuts as a source of β-sitosterol, a sterol with anticancer properties
    Awad, AB
    Chan, KC
    Downie, AC
    Fink, CS
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2000, 36 (02): : 238 - 241
  • [9] Effect of dietary phytosterols on cell proliferation and protein kinase C activity in rat colonic mucosa
    Awad, AB
    Hernandez, AYT
    Fink, CS
    Mendel, SL
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1997, 27 (02): : 210 - 215
  • [10] Awad AB, 2000, ANTICANCER RES, V20, P821