Holey barrier: claudins and the regulation of brain endothelial permeability

被引：80

作者：

Matter, K ^{[1
]}

Balda, MS ^{[1
]}

机构：

[1] UCL, Inst Ophthalmol, Div Cell Biol, London EC1V 9EL, England

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 161卷 / 03期

基金：

英国惠康基金;

关键词：

blood-brain barrier; tight junction; paracellular permeability; occludin;

D O I：

10.1083/jcb.200304039

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endothelial tight junctions (TJs)* are an important functional part of the blood-brain barrier (131313). In this issue, Nitta et al. (2003) demonstrate that claudin-5, a transmembrane protein of TJs, is a critical determinant of 131313 permeability in mice. Unexpectedly, knockout of claudin-5 did not result in a general breakdown of TJs but in a selective increase in paracellular permeability of small molecules. This suggests that the 131313 can be manipulated to allow selective diffusion of small molecules and makes claudin-5 a possible target for the development of drugs for this purpose.

引用

页码：459 / 460

页数：2

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