Roles of long non-coding RNA in osteoarthritis (Review)

被引：19

作者：

Wang, Jicheng ^{[1
]}

Sun, Yanshan ^{[1
]}

Liu, Jianyong ^{[1
]}

Yang, Bo ^{[1
]}

Wang, Tengyun ^{[1
]}

Zhang, Zhen ^{[1
]}

Jiang, Xin ^{[1
]}

Guo, Yongzhi ^{[1
]}

Zhang, Yangyang ^{[1
]}

机构：

[1] Weifang Peoples Hosp, Dept Joint Surg, 151 Guangwen St, Weifang 261000, Shandong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2021年 / 48卷 / 01期

关键词：

chondrocytes; transcriptional regulation; lncRNAs; non-coding RNAs; osteoarthritis; synoviocytes; INDUCED INFLAMMATORY INJURY; CHONDROCYTE EXTRACELLULAR-MATRIX; PROMOTES OSTEOARTHRITIS; KNEE OSTEOARTHRITIS; COLLAGEN SCAFFOLD; DOWN-REGULATION; EXPRESSION; CARTILAGE; MIAT; DEGRADATION;

D O I：

10.3892/ijmm.2021.4966

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Osteoarthritis (OA) is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation and is the most common form of arthritis. The clinical manifestations of OA are chronic pain and joint activity disorder, which severely affect the patient quality of life. Long non-coding RNA (lncRNA) is a class of RNA molecules >200 nucleotides long that are expressed in animals, plants, yeast, prokaryotes and viruses. lncRNA molecules lack an open reading frame and are not translated into protein. The present review collated the results of recent studies on the role of lncRNA in the pathogenesis of OA to provide information for the prevention, diagnosis and treatment of OA.

引用

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