Roles of long non-coding RNA in osteoarthritis (Review)

被引：19
作者：
Wang, Jicheng [1 ]
Sun, Yanshan [1 ]
Liu, Jianyong [1 ]
Yang, Bo [1 ]
Wang, Tengyun [1 ]
Zhang, Zhen [1 ]
Jiang, Xin [1 ]
Guo, Yongzhi [1 ]
Zhang, Yangyang [1 ]
机构：
[1] Weifang Peoples Hosp, Dept Joint Surg, 151 Guangwen St, Weifang 261000, Shandong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2021年 / 48卷 / 01期
关键词：
chondrocytes; transcriptional regulation; lncRNAs; non-coding RNAs; osteoarthritis; synoviocytes; INDUCED INFLAMMATORY INJURY; CHONDROCYTE EXTRACELLULAR-MATRIX; PROMOTES OSTEOARTHRITIS; KNEE OSTEOARTHRITIS; COLLAGEN SCAFFOLD; DOWN-REGULATION; EXPRESSION; CARTILAGE; MIAT; DEGRADATION;
D O I：
10.3892/ijmm.2021.4966
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Osteoarthritis (OA) is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation and is the most common form of arthritis. The clinical manifestations of OA are chronic pain and joint activity disorder, which severely affect the patient quality of life. Long non-coding RNA (lncRNA) is a class of RNA molecules >200 nucleotides long that are expressed in animals, plants, yeast, prokaryotes and viruses. lncRNA molecules lack an open reading frame and are not translated into protein. The present review collated the results of recent studies on the role of lncRNA in the pathogenesis of OA to provide information for the prevention, diagnosis and treatment of OA.
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页数：8
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共 110 条
[1]   Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis - structure, chaos and senescence [J].
Aigner, Thomas ;
Soeder, Stefan ;
Gebhard, Pia M. ;
McAlinden, Audrey ;
Haag, Jochen .
NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2007, 3 (07) :391-399
[2]   The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing [J].
Barry, G. ;
Briggs, J. A. ;
Vanichkina, D. P. ;
Poth, E. M. ;
Beveridge, N. J. ;
Ratnu, V. S. ;
Nayler, S. P. ;
Nones, K. ;
Hu, J. ;
Bredy, T. W. ;
Nakagawa, S. ;
Rigo, F. ;
Taft, R. J. ;
Cairns, M. J. ;
Blackshaw, S. ;
Wolvetang, E. J. ;
Mattick, J. S. .
MOLECULAR PSYCHIATRY, 2014, 19 (04) :486-494
[3]   LncRNA FOXD2-AS1 regulates chondrocyte proliferation in osteoarthritis by acting as a sponge of miR-206 to modulate CCND1 expression [J].
Cao, Lei ;
Wang, Yang ;
Wang, Qiugen ;
Huang, Jianhua .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 106 :1220-1226
[4]   Autophagy activation by rapamycin reduces severity of experimental osteoarthritis [J].
Carames, Beatriz ;
Hasegawa, Akihiko ;
Taniguchi, Noboru ;
Miyaki, Shigeru ;
Blanco, Francisco J. ;
Lotz, Martin .
ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (04) :575-581
[5]   Autophagy Is a Protective Mechanism in Normal Cartilage, and Its Aging-Related Loss Is Linked With Cell Death and Osteoarthritis [J].
Carames, Beatriz ;
Taniguchi, Noboru ;
Otsuki, Shuhei ;
Blanco, Francisco J. ;
Lotz, Martin .
ARTHRITIS AND RHEUMATISM, 2010, 62 (03) :791-801
[6]   LncRNA MEG3 Inhibits the Degradation of the Extracellular Matrix of Chondrocytes in Osteoarthritis via Targeting miR-93/TGFBR2 Axis [J].
Chen, Kang ;
Zhu, Hao ;
Zheng, Min-Qian ;
Dong, Qi-Rong .
CARTILAGE, 2021, 13 (2_SUPPL) :1274S-1284S
[7]   Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing [J].
Chen, Pengfei ;
Tao, Jiadong ;
Zhu, Shouan ;
Cai, Youzhi ;
Mao, Qijiang ;
Yu, Dongsheng ;
Dai, Jun ;
Ouyang, HongWei .
BIOMATERIALS, 2015, 39 :114-123
[8]   Long non-coding RNA highly up-regulated in liver cancer protects tumor necrosis factor-alpha-induced inflammatory injury by down-regulation of microRNA-101 in ATDC5 cells (Publication with Expression of Concern. See vol. 100, 2021) [J].
Chu, Peigang ;
Wang, Qiang ;
Wang, Zongru ;
Gao, Chunzheng .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2019, 72 :148-158
[9]   Methylene Blue Protects Liver Oxidative Capacity after Gut Ischaemia-Reperfusion in the Rat [J].
Collange, O. ;
Charles, A. -L. ;
Bouitbir, J. ;
Chenard, M. -P. ;
Zoll, J. ;
Diemunsch, P. ;
Thaveau, F. ;
Chakfe, N. ;
Piquard, F. ;
Geny, B. .
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2013, 45 (02) :168-175
[10]   Finishing the euchromatic sequence of the human genome [J].
Collins, FS ;
Lander, ES ;
Rogers, J ;
Waterston, RH .
NATURE, 2004, 431 (7011) :931-945
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