Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue

被引：2

作者：

Yoshida, Yohko ^{[1
,2
]}

Shimizu, Ippei ^{[1
]}

Hsiao, Yung-Ting ^{[1
]}

Suda, Masayoshi ^{[1
]}

Katsuumi, Goro ^{[1
]}

Seki, Masahide ^{[3
]}

Suzuki, Yutaka ^{[3
]}

Okuda, Shujiro ^{[4
]}

Soga, Tomoyoshi ^{[5
]}

Minamino, Tohru ^{[1
,6
]}

机构：

[1] Juntendo Univ, Dept Cardiovasc Biol & Med, Grad Sch Med, 2-1-1 Hongo,Bunkyo ku, Tokyo 1138421, Japan

[2] Juntendo Univ, Dept Adv Senotherapeut, Grad Sch Med, Tokyo 1138421, Japan

[3] Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Chiba 2778561, Japan

[4] Niigata Univ, Div Bioinformat, Grad Sch Med & Dent Sci, Niigata 9518510, Japan

[5] Keio Univ, Inst Adv Biosci, Yamagata 9970052, Japan

[6] Japan Agcy Med Res & Dev, Core Res Evolutionary Med Sci & Technol AMED CRES, Tokyo 1000004, Japan

来源：

ISCIENCE | 2022年 / 25卷 / 05期

关键词：

COLD-INDUCED THERMOGENESIS; FUNCTIONAL-CHARACTERIZATION; METABOLIC DYSFUNCTION; BEIGE ADIPOCYTES; GENE-EXPRESSION; FAT; ACTIVATION; OBESITY; MOUSE; DEFICIENCY;

D O I：

10.1016/j.isci.2022.104268

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Brown adipose tissue (BAT) is ametabolically active organ that contributes to the thermogenic response to cold exposure. In addition, other thermogenic cells termed beige adipocytes are generated in white adipose tissue (WAT) by cold exposure. Although activation of brown/beige adipose tissue is associated with mobilization of both glucose and lipids, few studies have focused on the role of glycolytic enzymes in regulating adipose tissue function. We generated mouse models with specific deletion of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) from adipose tissue. Deletion of Pgam1 from both BAT andWAT promoted whitening of BAT with beiging of visceral WAT, whereas deletion of Pgam1 from BAT alone led to whitening of BAT without beiging of WAT. Our results demonstrate a potential role of glycolytic enzymes in beiging of visceral WAT and suggest that PGAM1 would be a novel therapeutic target in obesity and diabetes.

引用

页数：21

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