Lack of effect of dopaminergic antagonists in a rodent model of peritoneal sepsis

被引：2

作者：

Albino Machado, Roberta ^{[1
]}

Constantino, Larissa ^{[1
]}

Rodrigo Martins, Marcio ^{[1
]}

Martins de Albuquerque, Isabella ^{[1
]}

Menna-Barreto, Sergio ^{[1
]}

Streck, Emilio ^{[1
]}

Quevedo, Joao ^{[1
]}

Dal-Pizzol, Felipe ^{[1
]}

机构：

[1] Univ Extremo Sul Catarinense, Lab Fisiopatol Expt, BR-88806000 Criciuma, SC, Brazil

来源：

CELL BIOLOGY INTERNATIONAL | 2007年 / 31卷 / 09期

关键词：

haloperidol; clozapine; dopamine; sepsis; CLP; immunomodulator;

D O I：

10.1016/j.cellbi.2007.03.022

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Central nervous system dopaminergic mechanisms have been implicated in the cytokine response to stress and sepsis. We here describe the effects of haloperidol or clozapine in the treatment of sepsis induced by cecal ligation and puncture. Male Wistar rats were subjected to the CLP procedure were treated with haloperidol or clozapine and plasma cytokines, myeloperoxidase activity, markers of organ injury and survival was analyzed. The addition of haloperidol or clozapine to basic support did not diminished hepatic, renal, pancreatic or muscular damage observed after sepsis. Neither haloperidol, nor clozapine, modulates pro and anti inflammatory cytokines after sepsis induction. In addition, haloperidol treatment did not diminished myeloperoxidase activity in the kidney, lung or liver, or altered BALF markers of lung damage or inflammatory infiltration. Our data did not support a role of haloperidol or clozapine as an immunomodulator agent in the treatment of sepsis in an animal model of peritonitis. (C) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

引用

页码：1036 / 1041

页数：6

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