Emerging treatment strategies for glioblastoma multiforme

被引：299

作者：

Carlsson, Steven K. ^{[1
]}

Brothers, Shaun P. ^{[1
]}

Wahlestedt, Claes ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Ctr Therapeut Innovat, Miami, FL 33136 USA

来源：

EMBO MOLECULAR MEDICINE | 2014年 / 6卷 / 11期

关键词：

biomarkers; brain imaging; cancer stem cells; epigenetics; glioblastoma multiforme (GBM); GROWTH-FACTOR RECEPTOR; CANCER STEM-CELLS; 5-AMINOLEVULINIC ACID; MALIGNANT GLIOMA; GUIDED RESECTION; PROGNOSTIC VALUE; SMALL-MOLECULE; TUMOR-GROWTH; TEMOZOLOMIDE; BRAIN;

D O I：

10.15252/emmm.201302627

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glioblastoma multiforme (GBM) is the deadliest form of brain tumor with a more than 90% 5-year mortality. GBM has a paltry median survival of 12.6months attributed to the unique treatment limitations such as the high average age of onset, tumor location, and poor current understandings of the tumor pathophysiology. The resection techniques, chemotherapic strategies, and radiation therapy currently used to treat GBM have slowly evolved, but the improvements have not translated to marked increases in patient survival. Here, we will discuss the recent progress in our understanding of GBM pathophysiology, and the diagnostic techniques and treatment options. The discussion will include biomarkers, tumor imaging, novel therapies such as monoclonal antibodies and small-molecule inhibitors, and the heterogeneity resulting from the GBM cancer stem cell population.

引用

页码：1359 / 1370

页数：12

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