Cardamonin attenuates chronic inflammation and tumorigenesis in colon

被引：28
作者：
Hou, Shasha [1 ,2 ]
Yuan, Qi [3 ]
Yu, Na [4 ]
Liu, Bin [5 ]
Huang, Gai [6 ]
Yuan, Xiaxia [7 ]
机构：
[1] Zaozhuang Univ, Coll Life Sci, Zaozhuang, Shandong, Peoples R China
[2] Qufu Normal Univ, Coll Life Sci, Qufu, Shandong, Peoples R China
[3] Beijing Jiaotong Univ, Coll Life Sci & Bioengn, Beijing, Peoples R China
[4] Shandong Univ, Shandong Xinchuang Biotechnol Co Ltd, Coll Clin Med, Shandong, Peoples R China
[5] Zaozhuang Min Grp, Zaozhuang Hosp, Dept Neurosurg, Zaozhuang, Shandong, Peoples R China
[6] Zaozhuang Min Grp, Zaozhuang Hosp, Dept Nursing, Zaozhuang, Shandong, Peoples R China
[7] Zaozhuang Univ, Coll City & Architecture Engn, Zaozhuang, Shandong, Peoples R China
来源：
CELL CYCLE | 2019年 / 18卷 / 23期
关键词：
Cardamonin; colon; inflammation; tumorigenesis; STAT; NF-KAPPA-B; IN-VITRO; CHALCONE DERIVATIVES; DOWN-REGULATION; CANCER; STAT3; COLITIS; PATHWAY; CELLS; INHIBIT;
D O I：
10.1080/15384101.2019.1673620
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cardamonin (CAD) is a member of the aromatic ketones family that is closely related to anti-bacterial, anti-inflammatory and anti-cancer effects. Nevertheless, the physiological function of cardamonin in chronic colitis and colon cancer has not been well verified. We found that cardamonin treatment alleviates intestinal disease, including recurring colitis and colitis-associated tumorigenesis, along with the reduced secretion of IL-1? and TNF-?. Further, cardamonin inhibits cell viability and inflammation factors of colorectal cancer cells in vitro. In tumor cells, the inhibitory effect of cardamonin on cell proliferation is closely related to decreased phosphorylation of signal transducers and activators of transcription (STAT) signals. This study reveals the crucial role of cardamonin in sustaining gastrointestinal homeostasis and offers a new strategy for colon cancer therapy.
引用
收藏
页码：3275 / 3287
页数：13
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