Synthesis of C5-substituted AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine

被引：24
作者：
Grangier, G
Trigg, WJ
Lewis, T
Rowan, MG
Potter, BVL
Blagbrough, IS [1 ]
机构：
[1] Univ Bath, Sch Pharm & Pharmacol, Dept Med Chem, Bath BA2 7AY, Avon, England
[2] Zeneca Agrochem, Jealotts Hill Res Stn, Bracknell RG12 6EY, Berks, England
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 08期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/S0040-4039(97)10648-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have prepared CS-substituted AE-bicyclic analogues of norditerpenoid alkaloids lycoctonine, inuline and methyllycaconitine via an acetylide anion addition strategy. Using two acetylide anions, we have regioselectively linked two cyclic ketones to acetylene. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：889 / 892
页数：4
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