Silver@Hydroxyapatite functionalized calcium carbonate composites: characterization, antibacterial and antibiofilm activities and cytotoxicity

被引：19

作者：

Ambrogi, Valeria ^{[1
]}

Quaglia, Giulia ^{[2
]}

Pietrella, Donatella ^{[3
]}

Nocchetti, Morena ^{[1
]}

Di Michele, Alessandro ^{[4
]}

Bolli, Eleonora ^{[5
,6
]}

Kaciulis, Saulius ^{[5
]}

Mezzi, Alessio ^{[5
]}

Padeletti, Giuseppina ^{[5
]}

Latterini, Loredana ^{[2
]}

机构：

[1] Univ Perugia, Dipartimento Sci Farmaceut, Via Liceo, I-06123 Perugia, Italy

[2] Univ Perugia, Dipartimento Chim Biol & Biotecnol, Nano4Light Lab, Perugia, Italy

[3] Univ Perugia, Dipartimento Med & Chirurg, Perugia, Italy

[4] Univ Perugia, Dipartimento Fis & Geol, Perugia, Italy

[5] CNR, ISMN, Inst Study Nanostruct Mat, Rome, Italy

[6] Univ Roma Tor Vergata, Dipartimento Ingn Ind, Rome, Italy

来源：

APPLIED SURFACE SCIENCE | 2022年 / 586卷

关键词：

Hydroxyapatite functionalized calcium carbonate; Silver composites; Antibacterial and antibiofilm activities; Cytotoxicity; NANOPARTICLES; AG3PO4; XPS; MICROPARTICLES; AGENT; METAL;

D O I：

10.1016/j.apsusc.2022.152760

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Silver@Hydroxyapatite functionalized calcium carbonate composites have been prepared through different sustainable methods, without involving the use of organic solvents and additional reagents. The composites were characterized by X-ray powder diffraction, field emission scanning electron microscopy, transmission electron microscopy, spectrophotometric measurements and X-ray photoemission spectroscopy. From the characterization techniques, the obtained nanoparticles resulted constituted essentially by Ag3PO4 nanostructures, whose size varied from 70 to 100 nm and were uniformly distributed on the calcium carbonate surface. Upon VIS irradiation, the formation of plasmonic nanostructures with a more defined dimensional distribution and reduced size could be obtained, as a prove of a partial silver reduction. All composites exhibited good antimicrobial and antibiofilm activities against Staphylococcus aureus and Pseudomonas aeruginosa whereas they showed low cytotoxicity effects towards human skin keratinocytes and human fibroblasts. These results enable these composites to be promising candidates for biomedical and pharmaceutical applications.

引用

页数：11

共 41 条

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