A resource of targeted mutant mouse lines for 5,061 genes

被引：68

作者：

Birling, Marie-Christine ^{[1
]}

Yoshiki, Atsushi ^{[2
]}

Adams, David J. ^{[3
]}

Ayabe, Shinya ^{[2
]}

Beaudet, Arthur L. ^{[4
,31
]}

Bottomley, Joanna ^{[3
]}

Bradley, Allan ^{[3
,32
]}

Brown, Steve D. M. ^{[5
]}

Buerger, Antje ^{[6
]}

Bushell, Wendy ^{[3
,33
]}

Chiani, Francesco ^{[7
]}

Chin, Hsian-Jean Genie ^{[8
]}

Christou, Skevoulla ^{[9
]}

Codner, Gemma F. ^{[9
]}

DeMayo, Francesco J. ^{[4
,34
]}

Dickinson, Mary E. ^{[4
]}

Doe, Brendan ^{[3
]}

Donahue, Leah Rae ^{[10
]}

Fray, Martin D. ^{[9
]}

Gambadoro, Alessia ^{[7
]}

Gao, Xiang ^{[11
]}

Gertsenstein, Marina ^{[12
]}

Gomez-Segura, Alba ^{[13
]}

Goodwin, Leslie O. ^{[10
]}

Heaney, Jason D. ^{[4
]}

Herault, Yann ^{[1
]}

de Angelis, Martin Hrabe ^{[14
,15
,16
]}

Jiang, Si-Tse ^{[8
]}

Justice, Monica J. ^{[4
,12
,17
]}

Kasparek, Petr ^{[18
]}

King, Ruairidh E. ^{[5
]}

Kuhn, Ralf ^{[6
,35
,36
]}

Lee, Ho ^{[19
,20
]}

Lee, Young Jae ^{[21
,22
]}

Liu, Zhiwei ^{[23
]}

Lloyd, K. C. Kent ^{[24
]}

Lorenzo, Isabel ^{[4
]}

Mallon, Ann-Marie ^{[5
]}

McKerlie, Colin ^{[12
,17
]}

Meehan, Terrence F. ^{[13
,37
]}

Fuentes, Violeta Munoz ^{[13
]}

Newman, Stuart ^{[3
,38
]}

Nutter, Lauryl M. J. ^{[12
,17
]}

Oh, Goo Taeg ^{[25
,26
]}

Pavlovic, Guillaume ^{[1
]}

Ramirez-Solis, Ramiro ^{[3
]}

Rosen, Barry ^{[3
,39
]}

Ryder, Edward J. ^{[3
,40
]}

Santos, Luis A. ^{[5
]}

Schick, Joel ^{[6
,41
]}

机构：

[1] Univ Strasbourg, CNRS, INSERM, PHENOMIN ICS,IGBMC, Illkirch Graffenstaden, France

[2] RIKEN BioResource Res Ctr, Tsukuba, Ibaraki, Japan

[3] Wellcome Sanger Inst, Hinxton, England

[4] Baylor Coll Med, Houston, TX 77030 USA

[5] MRC Harwell Inst, Mammalian Genet Unit, Didcot, Oxon, England

[6] German Res Ctr Environm Hlth, Inst Dev Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany

[7] Italian Natl Res Council CNR, Monterotondo Mouse Clin, Inst Cell Biol & Neurobiol, Monterotondo, Italy

[8] Natl Appl Res Labs NARLabs, Natl Lab Anim Ctr, Taipei, Taiwan

[9] MRC Harwell Inst, Mary Lyon Ctr, Didcot, Oxon, England

[10] Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA

[11] Nanjing Univ, Nanjing Biomed Res Inst, Collaborat Innovat Ctr Genet & Dev, SKL Pharmaceut Biotechnol & Model Anim Res Ctr, Nanjing, Peoples R China

[12] Ctr Phenogen, Toronto, ON, Canada

[13] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Hinxton, England

[14] German Res Ctr Environm Hlth, Inst Expt Genet, German Mouse Clin, Helmholtz Zentrum Munchen, Neuherberg, Germany

[15] Tech Univ Munich, Ctr Life & Food Sci Weihenstephan, Expt Genet, Freising Weihenstephan, Germany

[16] German Ctr Diabet Res, Neuherberg, Germany

[17] Hosp Sick Children, Toronto, ON, Canada

[18] Czech Acad Sci, Inst Mol Genet, Czech Ctr Phenogen, Vestec, Czech Republic

[19] Natl Canc Ctr, Korea Mouse Phenotyping Ctr KMPC, Gyeonggi, South Korea

[20] Natl Canc Ctr, Grad Sch Canc Sci & Policy, Gyeonggi, South Korea

[21] Gachon Univ, Korea Mouse Phenotyping Ctr KMPC, Incheon, South Korea

[22] Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Incheon, South Korea

[23] Soochow Univ, CAM SU Genom Resource Ctr, Suzhou, Peoples R China

[24] Univ Calif Davis, Mouse Biol Program, Davis, CA USA

[25] Ewha Womans Univ, Natl Creat Initiat, Immune & Vasc Cell Network Res Ctr, Seoul, South Korea

[26] Ewha Womans Univ, Dept Life Sci, Seoul, South Korea

[27] Seoul Natl Univ, Coll Vet Med, Korea Mouse Phenotyping Ctr KMPC, Seoul, South Korea

[28] Seoul Natl Univ, Coll Vet Med, BK21 Program Vet Sci, Res Inst Vet Sci, Seoul, South Korea

[29] Tech Univ Munich, Ctr Life & Food Sci Weihenstephan, Dev Genet, Freising Weihenstephan, Germany

[30] German Ctr Neurodegenerat Dis, Munich, Germany

[31] Luna Genet, Houston, TX USA

[32] Univ Cambridge, Cambridge Inst Therapeut Immunol & Infect Dis CIT, Jeffrey Cheah Biomed Ctr, Cambridge, England

[33] IONTAS, Cambridge, England

[34] Natl Inst Environm Hlth Sci Res, Durham, NC USA

[35] Max Delbrueck Ctr Mol Med, Berlin, Germany

[36] Berlin Inst Hlth, Berlin, Germany

[37] Kymab Grp, Cambridge, England

[38] PetMedix, Cambridge, England

[39] AstraZeneca, Discovery Sci, Cambridge, England

[40] LGC, Sport & Specialised Analyt Serv, Fordham, England

[41] Helmholtz Zentrum Munich, Inst Mol Toxicol & Pharmacol, Genet & Cellular Engn Grp, Neuherberg, Germany

[42] Jackson Lab Genom Med, Farmington, CT USA

[43] Kings Coll London, Wolfson Ctr Age Related Dis, London, England

来源：

NATURE GENETICS | 2021年 / 53卷 / 04期

基金：

欧盟地平线“2020”; 美国国家卫生研究院; 英国医学研究理事会; 国家重点研发计划; 新加坡国家研究基金会; 英国惠康基金;

关键词：

GENOME-WIDE; DISCOVERY; CONSORTIUM;

D O I：

10.1038/s41588-021-00825-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

引用

页码：416 / 419

页数：4

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