Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus Macaques

被引：42

作者：

Bonaldo, Myrna C. ^{[5
]}

Martins, Mauricio A. ^{[1
]}

Rudersdorf, Richard ^{[1
]}

Mudd, Philip A. ^{[1
]}

Sacha, Jonah B. ^{[1
]}

Piaskowski, Shari M. ^{[1
]}

Costa Neves, Patricia C. ^{[5
]}

Veloso de Santana, Marlon G. ^{[5
]}

Vojnov, Lara ^{[1
]}

Capuano, Saverio, III ^{[2
]}

Rakasz, Eva G. ^{[1
,2
]}

Wilson, Nancy A. ^{[1
,2
]}

Fulkerson, John ^{[3
]}

Sadoff, Jerald C. ^{[3
]}

Watkins, David I. ^{[1
,2
]}

Galler, Ricardo ^{[4
]}

机构：

[1] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53711 USA

[2] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA

[3] Aeras Global TB Vaccine Fdn, Rockville, MD USA

[4] Inst Tecnol Imunobiol, Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil

[5] Inst Oswaldo Cruz FIOCRUZ, Lab Biol Mol Flavivirus, Rio De Janeiro, Brazil

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 07期

关键词：

ANKARA BOOST REGIMEN; HIV-1; VACCINE; DISEASE PROGRESSION; VIRAL REPLICATION; CHALLENGE; IMMUNITY; MONKEYS; LYMPHOCYTES; PROTECTION; VECTORS;

D O I：

10.1128/JVI.02255-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here we describe a novel vaccine vector for expressing human immunodeficiency virus (HIV) antigens. We show that recombinant attenuated yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 Gag sequences can be used as a vector to generate SIV-specific CD8(+) T-cell responses in the rhesus macaque. Priming with recombinant BCG expressing SIV antigens increased the frequency of these SIV-specific CD8(+) T-cell responses after recombinant YF17D boosting. These recombinant YF17D-induced SIVspecific CD8(+) T cells secreted several cytokines, were largely effector memory T cells, and suppressed viral replication in CD4(+) T cells.

引用

页码：3699 / 3706

页数：8

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