Effects of fluconazole and clarithromycin on rifabutin and 25-O-desacetylrifabutin pharmacokinetics

被引：13

作者：

Jordan, MK

Polis, MA

Kelly, G

Narang, PK

Masur, H

Piscitelli, SC

机构：

[1] NIAID, NIH, Ctr Clin, Dept Pharm, Bethesda, MD 20892 USA

[2] NIAID, NIH, Dept Crit Care Med, Bethesda, MD 20892 USA

[3] NIAID, NIH, Immunoregulat Lab, Bethesda, MD 20892 USA

[4] Pharmacia & Upjohn Inc, Kalamazoo, MI 49001 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 08期

关键词：

D O I：

10.1128/AAC.44.8.2170-2172.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ten human immunodeficiency virus-infected patients were given rifabutin in addition to fluconazole and clarithromycin. There was a 76% increase in the area under the concentration-time curve of rifabutin when either fluconazole or clarithromycin was given alone and a 152% increase when both drugs were given together with rifabutin. Patients should be monitored for adverse effects of rifabutin administered concomitantly with clarithromycin and/or fluconazole.

引用

页码：2170 / 2172

页数：3

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