On-Water Synthesis of Biaryl Sulfonyl Fluorides

被引:46
作者
Chinthakindi, Praveen K. [1 ]
Kruger, Hendrik G. [1 ]
Govender, Thavendran [1 ]
Naicker, Tricia [1 ]
Arvidsson, Per I. [2 ,3 ]
机构
[1] Univ KwaZulu Natal, Catalysis & Peptide Res Unit, ZA-4041 Durban, South Africa
[2] Karolinska Inst, Drug Discovery & Dev Platform, Dept Med Biochem & Biophys, Sci Life Lab, SE-17121 Stockholm, Sweden
[3] Karolinska Inst, Div Translat Med & Chem Biol, Dept Med Biochem & Biophys, SE-17121 Stockholm, Sweden
基金
新加坡国家研究基金会;
关键词
CROSS-COUPLING REACTIONS; KINASE; ARYL; SULFONIMIDAMIDES; SITE; INACTIVATION; REACTIVITY; INHIBITORS; CHEMISTRY; SUBUNIT;
D O I
10.1021/acs.joc.5b02770
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Herein, we report an efficient, ligand-free, and additive-free Suzuki-Miyaura coupling that is compatible with the aromatic sulfonyl fluoride functional group. The protocol proceeds at room temperature, on water, and offers facile access to a wide range of biaryl sulfonyl fluorides as bioorthogonal "click" reagents.
引用
收藏
页码:2618 / 2623
页数:6
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