On-Water Synthesis of Biaryl Sulfonyl Fluorides

被引：46

作者：

Chinthakindi, Praveen K. ^{[1
]}

Kruger, Hendrik G. ^{[1
]}

Govender, Thavendran ^{[1
]}

Naicker, Tricia ^{[1
]}

Arvidsson, Per I. ^{[2
,3
]}

机构：

[1] Univ KwaZulu Natal, Catalysis & Peptide Res Unit, ZA-4041 Durban, South Africa

[2] Karolinska Inst, Drug Discovery & Dev Platform, Dept Med Biochem & Biophys, Sci Life Lab, SE-17121 Stockholm, Sweden

[3] Karolinska Inst, Div Translat Med & Chem Biol, Dept Med Biochem & Biophys, SE-17121 Stockholm, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

CROSS-COUPLING REACTIONS; KINASE; ARYL; SULFONIMIDAMIDES; SITE; INACTIVATION; REACTIVITY; INHIBITORS; CHEMISTRY; SUBUNIT;

D O I：

10.1021/acs.joc.5b02770

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report an efficient, ligand-free, and additive-free Suzuki-Miyaura coupling that is compatible with the aromatic sulfonyl fluoride functional group. The protocol proceeds at room temperature, on water, and offers facile access to a wide range of biaryl sulfonyl fluorides as bioorthogonal "click" reagents.

引用

页码：2618 / 2623

页数：6

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