Erythrocyte-Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal/Chemotherapy of Melanoma

被引：454

作者：

Wang, Dongdong ^{[1
]}

Dong, Haifeng ^{[1
]}

Li, Meng ^{[2
]}

Cao, Yu ^{[1
]}

Yang, Fan ^{[1
]}

Zhang, Kai ^{[1
]}

Dai, Wenhao ^{[1
]}

Wang, Changtao ^{[2
]}

Zhang, Xueji ^{[1
]}

机构：

[1] Univ Sci & Technol Beijing, Sch Chem & Bioengn, Res Ctr Bioengn & Sensing Technol, Beijing Key Lab Bioengn & Sensing Technol, Beijing 100083, Peoples R China

[2] Beijing Technol & Business Univ, Sch Sci, Beijing Key Lab Plant Resource Res & Dev, Beijing 100048, Peoples R China

来源：

ACS NANO | 2018年 / 12卷 / 06期

基金：

中国国家自然科学基金;

关键词：

cellular hybrid membrane; hollow copper sulfide nanoparticles; prolonged circulation lifetime; homotypic targeting; synergistic photothermal/chemotherapy; CONTROLLED DRUG-RELEASE; CELL-MEMBRANE; PHOTOTHERMAL THERAPY; PHOTODYNAMIC THERAPY; COATED NANOPARTICLES; THERANOSTIC AGENT; DELIVERY; NANOMATERIALS; METASTASIS;

D O I：

10.1021/acsnano.7b08355

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cellular-membrane-coated nanoparticles have increasingly been pursued to leverage the natural cell functions for enhancing biocompatibility and improved therapeutic efficacy. Taking advantage of specialized cell membranes or combining functions from different membrane types facilitates the strengthening of their functionality. Herein, we fuse membrane materials derived from red blood cells (RBCs) and melanoma cells (B16-F10 cells) to create a hybrid biomimetic coating (RBC-B16), and RBC-B16 hybrid membrane camouflaged doxorubicin (DOX)-loaded hollow copper sulfide nanoparticles (DCuS@[RBC-B16] NPs) are fabricated for combination therapy of melanoma. The DCuS@[RBC-B16] NPs are comprehensively characterized, showing the inherent properties of the both source cells. Compared to the bare CuS NPs, the DCuS@[RBC-B16] NPs exhibit highly specific self-recognition to the source cell line in vitro and achieve markedly prolonged circulation lifetime and enhanced homogeneous targeting abilities in vivo inherited from the source cells. Thus, the DOX-loaded [RBC-B16]-coated CuS NP platform exhibits excellent synergistic photothermal/chemotherapy with about 100% melanoma tumor growth inhibition rate. The reported strategy may contribute to personalized nanomedicine of various tumors by combining the RBCs with a homotypic cancer membrane accordingly on the surface of the nanoparticle.

引用

页码：5241 / 5252

页数：12

共 39 条

[21] Fabricating Aptamer-Conjugated PEGylated-MoS2/Cu1.8S Theranostic Nanoplatform for Multiplexed Imaging Diagnosis and Chemo-Photothermal Therapy of Cancer [J].

Meng, Xiangdan ;

Liu, Zhiqiang ;

Cao, Yu ;

Dai, Wenhao ;

Zhang, Kai ;

Dong, Haifeng ;

Feng, Xiaoyan ;

Zhang, Xueji .

ADVANCED FUNCTIONAL MATERIALS, 2017, 27 (16)

[22]

Molinaro R, 2016, NAT MATER, V15, P1037, DOI [10.1038/nmat4644, 10.1038/NMAT4644]

[23] Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions [J].

Parodi, Alessandro ;

Quattrocchi, Nicoletta ;

van de Ven, Anne L. ;

Chiappini, Ciro ;

Evangelopoulos, Michael ;

Martinez, Jonathan O. ;

Brown, Brandon S. ;

Khaled, Sm Z. ;

Yazdi, Iman K. ;

Vittoria Enzo, Maria ;

Isenhart, Lucas ;

Ferrari, Mauro ;

Tasciotti, Ennio .

NATURE NANOTECHNOLOGY, 2013, 8 (01) :61-68

[24] Erythrocyte Membrane Is an Alternative Coating to Polyethylene Glycol for Prolonging the Circulation Lifetime of Gold Nanocages for Photothermal Therapy [J].

Piao, Ji-Gang ;

Wang, Limin ;

Gao, Feng ;

You, Ye-Zi ;

Xiong, Yujie ;

Yang, Lihua .

ACS NANO, 2014, 8 (10) :10414-10425

[25] Hollow Copper Sulfide Nanoparticle-Mediated Transdermal Drug Delivery [J].

Ramadan, Samy ;

Guo, Liangran ;

Li, Yajuan ;

Yan, Bingfang ;

Lu, Wei .

SMALL, 2012, 8 (20) :3143-3150

[26] Antitumor Platelet-Mimicking Magnetic Nanoparticles [J].

Rao, Lang ;

Bu, Lin-Lin ;

Meng, Qian-Fang ;

Cai, Bo ;

Deng, Wei-Wei ;

Li, Andrew ;

Li, Kaiyang ;

Guo, Shi-Shang ;

Zhang, Wen-Feng ;

Liu, Wei ;

Sun, Zhi-Jun ;

Zhao, Xing-Zhong .

ADVANCED FUNCTIONAL MATERIALS, 2017, 27 (09)

[27] Cancer Cell Membrane-Coated Upconversion Nanoprobes for Highly Specific Tumor Imaging [J].

Rao, Lang ;

Bu, Lin-Lin ;

Cai, Bo ;

Xu, Jun-Hua ;

Li, Andrew ;

Zhang, Wen-Feng ;

Sun, Zhi-Jun ;

Guo, Shi-Shang ;

Liu, Wei ;

Wang, Tza-Huei ;

Zhao, Xing-Zhong .

ADVANCED MATERIALS, 2016, 28 (18) :3460-+

[28] Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Time and Reduced Accelerated Blood Clearance [J].

Rao, Lang ;

Bu, Lin-Lin ;

Xu, Jun-Hua ;

Cai, Bo ;

Yu, Guang-Tao ;

Yu, Xiaolei ;

He, Zhaobo ;

Huang, Qinqin ;

Li, Andrew ;

Guo, Shi-Shang ;

Zhang, Wen-Feng ;

Liu, Wei ;

Sun, Zhi-Jun ;

Wang, Hao ;

Wang, Tza-Huei ;

Zhao, Xing-Zhong .

SMALL, 2015, 11 (46) :6225-6236

[29] Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer [J].

Sun, Huiping ;

Su, Jinghan ;

Meng, Qingshuo ;

Yin, Qi ;

Chen, Lingli ;

Gu, Wangwen ;

Zhang, Zhiwen ;

Yu, Haijun ;

Zhang, Pengcheng ;

Wang, Siling ;

Li, Yaping .

ADVANCED FUNCTIONAL MATERIALS, 2017, 27 (03)

[30] Red Blood Cell-Facilitated Photodynamic Therapy for Cancer Treatment [J].

Tang, Wei ;

Zhen, Zipeng ;

Wang, Mengzhe ;

Wang, Hui ;

Chuang, Yen-Jun ;

Zhang, Weizhong ;

Wang, Geoffrey D. ;

Todd, Trever ;

Cowger, Taku ;

Chen, Hongmin ;

Liu, Lin ;

Li, Zibo ;

Xie, Jin .

ADVANCED FUNCTIONAL MATERIALS, 2016, 26 (11) :1757-1768

← 1 2 3 4 →