Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease

被引：88

作者：

Akboga, Mehmet Kadri ^{[1
]}

Balci, Kevser Gulcihan ^{[1
]}

Maden, Orhan ^{[1
]}

Ertem, Ahmet Goktug ^{[1
]}

Kirbas, Ozgur ^{[1
]}

Yayla, Cagri ^{[1
]}

Acar, Burak ^{[1
]}

Aras, Dursun ^{[1
]}

Kisacik, Halil ^{[1
]}

Aydogdu, Sinan ^{[1
]}

机构：

[1] Turkiye Yuksek Ihtisas Training & Res Hosp, Dept Cardiol, Ankara, Turkey

来源：

BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 04期

关键词：

high SYNTAX score; inflammation/oxidative stress; monocyte/HDL-cholesterol ratio; DENSITY-LIPOPROTEIN CHOLESTEROL; ACUTE CATHETERIZATION; INTERVENTION; SEVERITY; ATHEROSCLEROSIS; INFLAMMATION; ASSOCIATION; MORTALITY; BIOLOGY; EVENTS;

D O I：

10.2217/bmm-2015-0050

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. Patients & methods: In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were classified into two groups, low SYNTAX score (<= 22) and high SYNTAX score (>= 23). Results: MHRs were significantly higher in patients with high SYNTAX score (p < 0.05). In multivariate regression analysis, MHR remained as independent predictor of high SYNTAX score together with C-reactive protein (CRP), hypertension and diabetes mellitus. In correlation analysis, MHR showed significant positive correlations with SYNTAX score (r = 0.371, p < 0.001) and CRP level (r = 0.336, p < 0.001). Conclusion: This study suggests MHR is independently associated with burden of coronary atherosclerosis.

引用

页码：375 / 383

页数：9

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