共 37 条
12/15-Lipoxygenase inhibitor baicalein suppresses PPARγ expression and nuclear translocation induced by cerebral ischemia/reperfusion
被引:38
作者:

Xu, Yan-Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China

Sun, Li
论文数: 0 引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China

Liang, Hao
论文数: 0 引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China

Sun, Guo-Min
论文数: 0 引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China

Cheng, Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China
机构:
[1] Tianjin Med Univ, Tianjin Neurol Inst, Gen Hosp, Tian 300052, Peoples R China
来源:
基金:
中国国家自然科学基金;
关键词:
PPAR gamma (peroxisome proliferator-activated receptor gamma);
Ischemia/reperfusion;
Baicalein;
Translocation;
Rosiglitazone;
GW9662;
TRANSIENT FOCAL ISCHEMIA;
AGONIST ROSIGLITAZONE;
BRAIN-INJURY;
RECEPTOR;
ACTIVATION;
INFLAMMATION;
RATS;
15-LIPOXYGENASE;
PIOGLITAZONE;
LIGAND;
D O I:
10.1016/j.brainres.2009.10.038
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Accumulating evidences have demonstrated the beneficial actions of peroxisome proliferator-activated receptor gamma (PPAR gamma) in a variety of animal Stroke models. Following middle cerebral artery occlusion (60 min) and 2-24 hr reperfusion in rats, we observed cerebral ischemia/reperfusion (L/R) induced up-regulation of PPAP gamma protein expression and translocation from the cytoplasm into the nucleus in a time-dependent manner. We also found that PPAR gamma agonist rosiglitazone enhanced whereas PPAR gamma antagonist GW9662 inhibited the alteration of PPAR gamma stimulated by L/R, suggesting that the changes of PPAR gamma may result from the activation by endogenous ligands. Moreover, the link between the 12/15-lipoxygenase and the production of activating ligands for PPAR gamma has been proved in various tissues. However, the relation of them in brain tissue has not been identified. We demonstrated that the I/R-induced PPAR gamma alteration was reversed by baicalein, the specific inhibitor of 12/15-lipoxygenase. Baicalein treatment significantly inhibited the up-regulation of PPAR gamma expression and, furthermore, suppressed PPAR gamma nuclear accumulation as well as maintained PPAR gamma cytoplasmic retention. Together, these results suggest that I/R induces both PPAR gamma expression and translocation, probably through the activation by endogenous ligands in a 12/15-lipoxygenase inhibitor-sensitive way. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:149 / 157
页数:9
相关论文
共 37 条
- [1] 13-oxo-ODE is an endogenous ligand for PPARγ in human colonic epithelial cells[J]. BIOCHEMICAL PHARMACOLOGY, 2007, 74 (04) : 612 - 622Altmann, Reinhold论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandHausmann, Martin论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandSpoettl, Tanja论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandGruber, Michael论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandBull, Arthur W.论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandMenzel, Katrin论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandVogl, Daniela论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandHerfarth, Hans论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandSchoelmerich, Juergen论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandFalk, Werner论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, SwitzerlandRogler, Gerhard论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Dept Internal Med, CH-8091 Zurich, Switzerland
- [2] IL-13 induces expression of CD36 in human monocytes through PPARγ activation[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (06) : 1642 - 1652Berry, Antoine论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, FranceBalard, Patricia论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, FranceCoste, Agnes论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, France论文数: 引用数: h-index:机构:Laganel, Celine论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, France论文数: 引用数: h-index:机构:Benoit-Vical, Francoise论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, FranceLepert, Jean-Claude论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, FranceSeguela, Jean-Paul论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, France论文数: 引用数: h-index:机构:Chambon, Pierre论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, FranceMetzger, Daniel论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, France论文数: 引用数: h-index:机构:Wahli, Walter论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, FranceAuwerx, Johan论文数: 0 引用数: 0 h-index: 0机构: Univ Toulouse 3, INSERM, IFR 31, EA2405, F-31432 Toulouse, France论文数: 引用数: h-index:机构:
- [3] Peroxisome proliferator-activated receptor (PPAR)γ is highly expressed in normal human pituitary gland[J]. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2005, 28 (10) : 899 - 904论文数: 引用数: h-index:机构:Russo, D论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyLocci, MT论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyChifenti, B论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyUltimieri, F论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyRaggi, F论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyViacava, P论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyCecchetti, D论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyCosci, C论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalySardella, C论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyAcerbi, G论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyGasperi, M论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, ItalyMartino, E论文数: 0 引用数: 0 h-index: 0机构: Univ Pisa, Dipartimento Endocrinol & Metab, Osped Cisanello, I-56124 Pisa, Italy
- [4] Diabetes Mellitus and macrovascular disease: Mechanisms and mediators[J]. AMERICAN JOURNAL OF MEDICINE, 2007, 120 (09) : S12 - S17Boyle, Patrick J.论文数: 0 引用数: 0 h-index: 0机构: Univ New Mexico, Dept Med, Albuquerque, NM 87131 USA Univ New Mexico, Dept Med, Albuquerque, NM 87131 USA
- [5] Human articular chondrocytes express 15-lipoxygenase-1 and-2: potential role in osteoarthritis[J]. ARTHRITIS RESEARCH & THERAPY, 2009, 11 (02)Chabane, Nadir论文数: 0 引用数: 0 h-index: 0机构: Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, Canada Univ Montreal, Dept Med, Montreal, PQ H2L 4M1, Canada Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, CanadaZayed, Nadia论文数: 0 引用数: 0 h-index: 0机构: Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, Canada Univ Montreal, Dept Med, Montreal, PQ H2L 4M1, Canada Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, CanadaBenderdour, Mohamed论文数: 0 引用数: 0 h-index: 0机构: Hop Sacre Coeur, Res Ctr, Montreal, PQ H4J 1C5, Canada Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, CanadaMartel-Pelletier, Johanne论文数: 0 引用数: 0 h-index: 0机构: Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, Canada Univ Montreal, Dept Med, Montreal, PQ H2L 4M1, Canada Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, CanadaPelletier, Jean-Pierre论文数: 0 引用数: 0 h-index: 0机构: Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, Canada Univ Montreal, Dept Med, Montreal, PQ H2L 4M1, Canada Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, CanadaDuval, Nicolas论文数: 0 引用数: 0 h-index: 0机构: Ctr Convalescence, Montreal, PQ H7M 2Y3, Canada Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, CanadaFahmi, Hassan论文数: 0 引用数: 0 h-index: 0机构: Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, Canada Univ Montreal, Dept Med, Montreal, PQ H2L 4M1, Canada Univ Montreal, Notre Dame Hosp, Hosp Ctr CRCHUM, Osteoarthritis Res Unit,Res Ctr, Montreal, PQ H2L 4M1, Canada
- [6] Modulation of the oxidative stress and inflammatory response by PPAR-γ agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 530 (1-2) : 70 - 80Collino, M论文数: 0 引用数: 0 h-index: 0机构: Univ Turin, Dept Anat Pharmacol & Forens Med, I-10125 Turin, Italy论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Gallichio, M论文数: 0 引用数: 0 h-index: 0机构: Univ Turin, Dept Anat Pharmacol & Forens Med, I-10125 Turin, ItalyRosa, AC论文数: 0 引用数: 0 h-index: 0机构: Univ Turin, Dept Anat Pharmacol & Forens Med, I-10125 Turin, Italy论文数: 引用数: h-index:机构:Danni, O论文数: 0 引用数: 0 h-index: 0机构: Univ Turin, Dept Anat Pharmacol & Forens Med, I-10125 Turin, ItalyThiemermann, C论文数: 0 引用数: 0 h-index: 0机构: Univ Turin, Dept Anat Pharmacol & Forens Med, I-10125 Turin, Italy论文数: 引用数: h-index:机构:
- [7] Rosiglitazone attenuates allergic inflammation and inhibits expression of galectin-3 in a mouse model of allergic rhinitis[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2008, 36 (04) : 830 - 836Han, J. L.论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R China China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R ChinaDing, R. Y.论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R China China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R ChinaZhao, L.论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R China China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R ChinaRen, Z.论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R China China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R ChinaJiang, X. J.论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R China China Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Shenyang 110001, MA, Peoples R China
- [8] Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity:: Evidence for the involvement of transcription factor STAT6[J]. BLOOD, 1998, 92 (07) : 2503 - 2510Heydeck, D论文数: 0 引用数: 0 h-index: 0机构: Humboldt Univ, Clin Charite, Inst Biochem, D-10115 Berlin, GermanyThomas, L论文数: 0 引用数: 0 h-index: 0机构: Humboldt Univ, Clin Charite, Inst Biochem, D-10115 Berlin, GermanySchnurr, K论文数: 0 引用数: 0 h-index: 0机构: Humboldt Univ, Clin Charite, Inst Biochem, D-10115 Berlin, GermanyTrebus, F论文数: 0 引用数: 0 h-index: 0机构: Humboldt Univ, Clin Charite, Inst Biochem, D-10115 Berlin, GermanyThierfelder, WE论文数: 0 引用数: 0 h-index: 0机构: Humboldt Univ, Clin Charite, Inst Biochem, D-10115 Berlin, GermanyIhle, JN论文数: 0 引用数: 0 h-index: 0机构: Humboldt Univ, Clin Charite, Inst Biochem, D-10115 Berlin, GermanyKühn, H论文数: 0 引用数: 0 h-index: 0机构: Humboldt Univ, Clin Charite, Inst Biochem, D-10115 Berlin, Germany
- [9] Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase[J]. NATURE, 1999, 400 (6742) : 378 - 382Huang, JT论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAWelch, JS论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USARicote, M论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USABinder, CJ论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAWillson, TM论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAKelly, C论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAWitztum, JL论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAFunk, CD论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAConrad, D论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAGlass, CK论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USA
- [10] Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats[J]. NEUROSCIENCE LETTERS, 2008, 432 (03) : 198 - 201Hunter, Randy L.论文数: 0 引用数: 0 h-index: 0机构: Univ Kentucky, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky, Chandler Med Ctr, Dept Anat & Neurobiol, Lexington, KY 40536 USAChoi, Dong-Young论文数: 0 引用数: 0 h-index: 0机构: Univ Kentucky, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky, Chandler Med Ctr, Dept Anat & Neurobiol, Lexington, KY 40536 USARoss, Stuart A.论文数: 0 引用数: 0 h-index: 0机构: Univ Kentucky, Pediat Diabet Ctr, Lexington, KY 40536 USA Univ Kentucky, Chandler Med Ctr, Dept Anat & Neurobiol, Lexington, KY 40536 USABing, Guoying论文数: 0 引用数: 0 h-index: 0机构: Univ Kentucky, Chandler Med Ctr, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky, Chandler Med Ctr, Dept Anat & Neurobiol, Lexington, KY 40536 USA