Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media

Tuning molecular structures of self-assembling multivalent (SAMul) dendritic cationic lipopeptides controls the self- assembled morphology. In buffer, spherical micelles formed by higher generation systems bind polyanionic heparin better than worm-like micelles formed by lower generation systems. In human serum, the binding of sphericalmicelles to heparin is adversely affected, while worm- like micelles maintain their relative binding ability.