Infections and malignancies risks related to TNF-α-blocking agents in pediatric inflammatory bowel diseases

被引：13

作者：

Alvisi, Patrizia ^{[1
]}

Dipasquale, Valeria ^{[2
]}

Barabino, Arrigo ^{[3
]}

Martellossi, Stefano ^{[4
]}

Miele, Erasmo ^{[5
,6
]}

Lionetti, Paolo ^{[7
]}

Lombardi, Giuliano ^{[8
]}

Cucchiara, Salvatore ^{[9
]}

Torre, Giuliano ^{[10
]}

Romano, Claudio ^{[2
]}

机构：

[1] Maggiore Hosp, Pediat Gastroenterol Unit, Bologna, Italy

[2] Univ Messina, Dept Human Pathol Adulthood & Childhood G Barresi, Pediat Gastroenterol Unit, Messina, Italy

[3] Inst Giannina Gaslini, Pediat Gastroenterol Unit, Genoa, Italy

[4] Inst Maternal & Child Hlth IRCCS Burlo Garofalo, Gastroenterol Digest Endoscopy & Nutr Unit, Dept Pediat, Trieste, Italy

[5] Univ Federico II, Sect Pediat, Dept Translat Med Sci, Naples, Italy

[6] Univ Federico II, European Lab Invest Food Induced Dis, Naples, Italy

[7] Univ Florence, Meyer Hosp, Pediat Gastroenterol & Nutr Unit, Florence, Italy

[8] Spirito Santo Hosp, Pediat Gastroenterol & Endoscopy Unit, Pescara, Italy

[9] Sapienza Univ Rome, Pediat Gastroenterol & Liver Unit, Dept Pediat & Infantile Neuropsychiat, Rome, Italy

[10] Bambino Gesu Pediat Hosp, Hepatol Gastroenterol & Nutr Unit, Rome, Italy

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2019年 / 13卷 / 10期

关键词：

Inflammatory bowel disease; child; biological therapy; TNF-alpha; safety; NECROSIS-FACTOR-ALPHA; JUVENILE IDIOPATHIC ARTHRITIS; EVIDENCE-BASED CONSENSUS; LONG-TERM SAFETY; CROHNS-DISEASE; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; OPPORTUNISTIC INFECTIONS; ULCERATIVE-COLITIS; FACTOR THERAPY; CHILDREN;

D O I：

10.1080/17474124.2019.1663173

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Introduction: Tumor necrosis factor-alpha (TNF-alpha)-blocking agents are drugs approved for the treatment of inflammatory bowel diseases (IBDs). Infliximab and adalimumab are approved for the treatment of IBD in the pediatric setting with the improvement of therapeutic management. Biological agents, also in the pediatric population, can be administered either alone or in combination with immunomodulators. Their use has raised safety concerns regarding the risk of infections and malignancies. Areas covered: A broad review of the safety concerns for the use of anti-TNF-alpha drugs in children with IBD was performed, and information regarding the risk of infections and malignancies were updated, also in comparison with the safety of traditional drugs such as steroids and/or immunosuppressants. Expert commentary: Anti-TNF-alpha drugs have shown favorable safety profiles, and adalimumab treatment is associated with lower immunogenicity compared with infliximab. Heightened awareness and vigilant surveillance leading to prompt diagnosis and treatment are important for optimal management.

引用

页码：957 / 961

页数：5

共 45 条

[31] Mechanisms of Pediatric Inflammatory Bowel Disease
Peloquin, Joanna M.
Goel, Gautam
Villablanca, Eduardo J.
Xavier, Ramnik J.
[J]. ANNUAL REVIEW OF IMMUNOLOGY, VOL 34, 2016, 34 : 31 - 64
[32] Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease
Rahier, J. F.
Magro, F.
Abreu, C.
Armuzzi, A.
Ben-Horin, S.
Chowers, Y.
Cottone, M.
de Ridder, L.
Doherty, G.
Ehehalt, R.
Esteve, M.
Katsanos, K.
Lees, C. W.
MacMahon, E.
Moreels, T.
Reinisch, W.
Tilg, H.
Tremblay, L.
Veereman-Wauters, G.
Viget, N.
Yazdanpanah, Y.
Eliakim, R.
Colombel, J. F.
[J]. JOURNAL OF CROHNS & COLITIS, 2014, 8 (06) : 443 - 468
[33] Epstein-Barr Virus-associated Lymphoproliferative Disorder in Crohn Disease Treated With Azathioprine
Ross, Sherina
Rajwal, Sanjay Kumar
Sugarman, Ian
Picton, Susan
Devlin, James
Davison, Suzanne
McClean, Patricia
[J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2010, 51 (02) : 229 - 231
[34] A British Society of Paediatric Gastroenterology, Hepatology and Nutrition survey of the effectiveness and safety of adalimumab in children with inflammatory bowel disease
Russell, R. K.
Wilson, M. L.
Loganathan, S.
Bourke, B.
Kiparissi, F.
Mahdi, G.
Torrente, F.
Rodrigues, A.
Davies, I.
Thomas, A.
Akobeng, A. K.
Fagbemi, A.
Hyer, W.
Spray, C.
Vaish, S.
Rogers, P.
McGrogan, P.
Heuschkel, R. B.
Ayub, N.
Fell, J. M.
Afzal, N. A.
Green, M.
Murphy, M. S.
Rao, P.
Shah, N.
Ho, G. -T.
Naik, S.
Wilson, D. C.
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 33 (08) : 946 - 953
[35] Use of case reports and the Adverse Event Reporting System in systematic reviews: overcoming barriers to assess the link between Crohn's disease medications and hepatosplenic T-cell lymphoma.
Selvaraj S.A.
Chairez E.
Wilson L.M.
Lazarev M.
Bass E.B.
Hutfless S.
[J]. Systematic Reviews, 2 (1) : 53
[36] Risk of Lymphoma Associated With Combination Anti-Tumor Necrosis Factor and Immunomodulator Therapy for the Treatment of Crohn's Disease: A Meta-Analysis
Siegel, Corey A.
Marden, Sadie M.
Persing, Sarah M.
Larson, Robin J.
Sands, Bruce E.
[J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2009, 7 (08) : 874 - 881
[37] Inflammatory bowel disease caused by primary immunodeficienciesClinical presentations, review of literature, and proposal of a rational diagnostic algorithm
Tegtmeyer, Daniel
Seidl, Maximilian
Gerner, Patrick
Baumann, Ulrich
Klemann, Christian
[J]. PEDIATRIC ALLERGY AND IMMUNOLOGY, 2017, 28 (05) : 412 - 429
[38] Hepatosplenic T-cell lymphoma and inflammatory bowel disease
Thai, Anne
Prindiville, Thomas
[J]. JOURNAL OF CROHNS & COLITIS, 2010, 4 (05) : 511 - 522
[39] Risk factors for opportunistic infections in patients with inflammatory bowel disease
Toruner, Murat
Loftus, Edward V., Jr.
Harmsen, W. Scott
Zinsmeister, Alan R.
Orenstein, Robert
Sandborn, William J.
Colombel, Jean-Frederic
Egan, Laurence J.
[J]. GASTROENTEROLOGY, 2008, 134 (04) : 929 - 936
[40] Infections in Children and Adolescents With Juvenile Idiopathic Arthritis and Inflammatory Bowel Disease Treated With Tumor Necrosis Factor-α Inhibitors: Systematic Review of the Literature
Toussi, Sima S.
Pan, Nancy
Walters, Heather M.
Walsh, Thomas J.
[J]. CLINICAL INFECTIOUS DISEASES, 2013, 57 (09) : 1318 - 1330

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