New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics

被引：65

作者：

He, Mingjing ^{[1
,2
,3
]}

Zhou, Zhuan ^{[1
,2
]}

Shah, Anil A. ^{[1
,2
]}

Hong, Yang ^{[1
,2
]}

Chen, Qianming ^{[3
]}

Wan, Yong ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Cell Biol, 5117 Ctr Ave,HCC2-6c, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr, 5117 Ctr Ave,HCC2-6c, Pittsburgh, PA 15213 USA

[3] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China

来源：

CELL DIVISION | 2016年 / 11卷

关键词：

Hippo pathway; Posttranslational modifications; Phosphorylation; Ubiquitylation; Sumoylation; Acetylation; Methylation; Cancer and anti-cancer treatment; YES-ASSOCIATED PROTEIN; TUMOR-SUPPRESSOR; SIGNALING PATHWAY; CELL-PROLIFERATION; YAP; PHOSPHORYLATION; KINASE; ANTAGONIZES; INHIBITORS; TAZ;

D O I：

10.1186/s13008-016-0013-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of signaling proteins, facilitating the initiation, amplification and transduction of signaling. Accumulating evidence suggest that several key signaling molecules in Hippo signaling pathway are tightly regulated by various types of PTMs. Malfunction of these critical signaling modules such as YAP/TAZ, MAT1/2 and LATS1/2 due to deregulated PTMs has been linked to a variety of human diseases such as cancer. In this review article, we summarized the current understanding of the impact of PTMs in regulating Hippo signaling pathway and further discussed the potential therapeutic intervention from the view of PTMs and Hippo pathway.

引用

页数：10

共 53 条

[1] c-Jun N-terminal Kinase Enhances MST1-mediated Pro-apoptotic Signaling through Phosphorylation at Serine 82 [J].

Bi, Wenzhi ;

Xiao, Lei ;

Jia, Yunfeng ;

Wu, Junbing ;

Xie, Qi ;

Ren, Jian ;

Ji, Guangju ;

Yuan, Zengqiang .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (09) :6259-6264

[2] Tao-1 Phosphorylates Hippo/MST Kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway [J].

Boggiano, Julian C. ;

Vanderzalm, Pamela J. ;

Fehon, Richard G. .

DEVELOPMENTAL CELL, 2011, 21 (05) :888-895

[3] CYLD negatively regulates Hippo signaling by limiting Hpo phosphorylation in Drosophila [J].

Chen, Yan ;

Wang, Zaizhu ;

Wang, Ping ;

Li, Dengwen ;

Zhou, Jun ;

Wu, Shian .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 452 (03) :808-812

[4] Threonine-120 Phosphorylation Regulated by Phosphoinositide-3-Kinase/Akt and Mammalian Target of Rapamycin Pathway Signaling Limits the Antitumor Activity of Mammalian Sterile 20-Like Kinase 1 [J].

Collak, Filiz Kisaayak ;

Yagiz, Kader ;

Luthringer, Daniel J. ;

Erkaya, Bahriye ;

Cinar, Bekir .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (28) :23698-23709

[5] The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells [J].

Cordenonsi, Michelangelo ;

Zanconato, Francesca ;

Azzolin, Luca ;

Forcato, Mattia ;

Rosato, Antonio ;

Frasson, Chiara ;

Inui, Masafumi ;

Montagner, Marco ;

Parenti, Anna R. ;

Poletti, Alessandro ;

Daidone, Maria Grazia ;

Dupont, Sirio ;

Basso, Giuseppe ;

Bicciato, Silvio ;

Piccolo, Stefano .

CELL, 2011, 147 (04) :759-772

[6] Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers [J].

Cottini, Francesca ;

Hideshima, Teru ;

Xu, Chunxiao ;

Sattler, Martin ;

Dori, Martina ;

Agnelli, Luca ;

ten Hacken, Elisa ;

Bertilaccio, Maria Teresa ;

Antonini, Elena ;

Neri, Antonino ;

Ponzoni, Maurilio ;

Marcatti, Magda ;

Richardson, Paul G. ;

Carrasco, Ruben ;

Kimmelman, Alec C. ;

Wong, Kwok-Kin ;

Caigaris-Cappio, Federico ;

Blandino, Giovanni ;

Kuehl, W. Michael ;

Anderson, Kenneth C. ;

Tonon, Giovanni .

NATURE MEDICINE, 2014, 20 (06) :599-606

[7] The Tumor Suppressor RASSF1A Prevents Dephosphorylation of the Mammalian STE20-like Kinases MST1 and MST2 [J].

Guo, Cai ;

Zhang, Xiaoying ;

Pfeifer, Gerd P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (08) :6253-6261

[8] The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis [J].

Hamaratoglu, F ;

Willecke, M ;

Kango-Singh, M ;

Nolo, R ;

Hyun, E ;

Tao, CY ;

Jafar-Nejad, H ;

Halder, G .

NATURE CELL BIOLOGY, 2006, 8 (01) :27-U9

[9] The Hippo pathway and human cancer [J].

Harvey, Kieran F. ;

Zhang, Xiaomeng ;

Thomas, David M. .

NATURE REVIEWS CANCER, 2013, 13 (04) :246-257

[10] A Novel Acetylation Cycle of Transcription Co-activator Yes-associated Protein That Is Downstream of Hippo Pathway Is Triggered in Response to SN2 Alkylating Agents [J].

Hata, Shoji ;

Hirayama, Jun ;

Kajiho, Hiroaki ;

Nakagawa, Kentaro ;

Hata, Yutaka ;

Katada, Toshiaki ;

Furutani-Seiki, Makoto ;

Nishina, Hiroshi .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (26) :22089-22098

← 1 2 3 4 5 6 →