Micron-scale hysteresis measurement using dynamic optical coherence elastography

被引:3
作者
Li, Wenjie [1 ]
Feng, Jinping [2 ]
Wang, Yicheng [1 ]
Shi, Qun [1 ]
Ma, Guoqin [1 ]
Aglyamov, Salavat [3 ]
Larin, Kirill, V [4 ]
Lan, Gongpu [5 ,6 ]
Twa, Michael [7 ]
机构
[1] Foshan Univ, Sch Mechatron Engn & Automat, Foshan 528000, Guangdong, Peoples R China
[2] Hubei Univ Sci & Technol, Inst Engn & Technol, Xianning 437100, Hubei, Peoples R China
[3] Univ Houston, Mech Engn, Houston, TX 77204 USA
[4] Univ Houston, Biomed Engn, Houston, TX 77204 USA
[5] Foshan Univ, Sch Phys & Optoelect Engn, Guangdong Hong Kong Macao Joint Lab Intelligent M, Foshan 528000, Guangdong, Peoples R China
[6] Weiren Meditech Co Ltd, Innovat & Entrepreneurship Team Guangdong Pearl R, Foshan 528000, Guangdong, Peoples R China
[7] Univ Houston, Coll Optometry, Houston, TX 77204 USA
基金
中国国家自然科学基金;
关键词
MAGNETIC-RESONANCE ELASTOGRAPHY; BIOMECHANICAL PROPERTIES; IN-VIVO; LEFT-VENTRICLE; RABBIT CORNEA; DEFORMATION; TOMOGRAPHY; ELASTICITY; ULTRASOUND; RETRACTION;
D O I
10.1364/BOE.457617
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We present a novel optical coherence elastography (OCE) method to characterize mechanical hysteresis of soft tissues based on transient (milliseconds), low-pressure (<20 Pa) non-contact microliter air-pulse stimulation and micrometer-scale sample displacements. The energy dissipation rate (sample hysteresis) was quantified for soft-tissue phantoms (0.8% to 2.0% agar) and beef shank samples under different loading forces and displacement amplitudes. Sample hysteresis was defined as the loss ratio (hysteresis loop area divided by the total loading energy). The loss ratio was primarily driven by the sample unloading response which decreased as loading energy increased. Samples were distinguishable based on their loss ratio responses as a function loading energy or displacement amplitude. Finite element analysis and mechanical testing methods were used to validate these observations. We further performed the OCE measurements on a beef shank tissue sample to distinguish the muscle and connective tissue components based on the displacement and hysteresis features. This novel, noninvasive OCE approach has the potential to differentiate soft tissues by quantifying their viscoelasticity using micron-scale transient tissue displacement dynamics. Focal tissue hysteresis measurements could provide additional clinically useful metrics for guiding disease diagnosis and tissue treatment responses. (C) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
引用
收藏
页码:3021 / 3041
页数:21
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