Towards real-time in-implant epileptic seizure prediction

被引:0
作者
Aziz, Joseph N. Y. [1 ]
Karakiewiez, Rafal [1 ]
Genov, Roman [1 ]
Bardakjian, Berj L. [1 ]
Derchansky, Miron [2 ]
Carlen, Peter L. [2 ]
机构
[1] Univ Toronto, Dept Elect & Comp Engn, Toronto, ON M5S 3G4, Canada
[2] Univ Toronto, Toronto Western Hosp, Krembil Neurosci Ctr, Dept Physiol & Med, Toronto, ON M5S 1A1, Canada
来源
2006 28TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-15 | 2006年
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中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
We present an architecture of an epileptic seizure prediction system suitable for an implantable implementation. The microsystem comprises a neural interface, a spectral analysis processor and an artificial neural network (ANN). The neural interface and the spectral analysis processor have been prototyped in a 0.35 mu m CNOS technology with experimental results are presented. The wavelet-based artificial neural network predicts the onsets of seizure up to two minutes before their occurrence in an in-vitro epilepsy model using a mouse hippocampal brain slice with recurrent spontaneous seizures.
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页码:5307 / +
页数:2
相关论文
共 19 条
[1]   Decreased susceptibility to pentylenetetrazol-induced seizures after low-frequency transcranial magnetic stimulation in rats [J].
Akamatsu, N ;
Fueta, Y ;
Endo, Y ;
Matsunaga, K ;
Uozumi, T ;
Tsuji, S .
NEUROSCIENCE LETTERS, 2001, 310 (2-3) :153-156
[2]   Vagus-nerve stimulation for the treatment of epilepsy [J].
Ben-Menachem, E .
LANCET NEUROLOGY, 2002, 1 (08) :477-482
[3]   Prediction of seizure onset in an in-vitro hippocampal slice model of epilepsy using Gaussian-based and wavelet-based artificial neural networks [J].
Chiu, AWL ;
Daniel, S ;
Khosravani, H ;
Carlen, PL ;
Bardakjian, BL .
ANNALS OF BIOMEDICAL ENGINEERING, 2005, 33 (06) :798-810
[4]   Control of state transitions in an in silico model of epilepsy using small perturbations [J].
Chiu, AWL ;
Bardakjian, BL .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2004, 51 (10) :1856-1859
[5]   Emerging surgical and radiotherapeutic techniques for treating epilepsy [J].
Cohen-Gadol, AA ;
Stoffman, MR ;
Spencer, DD .
CURRENT OPINION IN NEUROLOGY, 2003, 16 (02) :213-219
[6]   Model of frequent, recurrent, and spontaneous seizures in the intact mouse hippocampus [J].
Derchansky, M ;
Shahar, E ;
Wennberg, RA ;
Samoilova, M ;
Jahromi, SS ;
Abdelmalik, PA ;
Zhang, L ;
Carlen, PL .
HIPPOCAMPUS, 2004, 14 (08) :935-947
[7]   Kerneltron: Support vector "machine" in silicon [J].
Genov, R ;
Cauwenberghs, G .
IEEE TRANSACTIONS ON NEURAL NETWORKS, 2003, 14 (05) :1426-1434
[8]   Charge-mode parallel architecture for vector-matrix multiplication [J].
Genov, R ;
Cauwenberghs, G .
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-ANALOG AND DIGITAL SIGNAL PROCESSING, 2001, 48 (10) :930-936
[9]   Effects of applied electric fields on low-calcium epileptiform activity in the CA1 region of rat hippocampal slices [J].
Ghai, RS ;
Bikson, M ;
Durand, DM .
JOURNAL OF NEUROPHYSIOLOGY, 2000, 84 (01) :274-280
[10]   Adaptive electric field control of epileptic seizures [J].
Gluckman, BJ ;
Nguyen, H ;
Weinstein, SL ;
Schiff, SJ .
JOURNAL OF NEUROSCIENCE, 2001, 21 (02) :590-600