The use of CD47-modified biomaterials to mitigate the immune response

被引:22
作者
Tengood, Jillian E. [1 ,2 ]
Levy, Robert J. [1 ,2 ]
Stachelek, Stanley J. [1 ,2 ]
机构
[1] Childrens Hosp Philadelphia, Dept Pediat, Div Cardiol, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
关键词
CD47; signal regulatory protein alpha; biomaterials; inflammation; ALVEOLAR MACROPHAGE PHAGOCYTOSIS; HEMATOPOIETIC STEM-CELLS; FOREIGN-BODY REACTION; SURFACTANT PROTEIN-A; IN-VIVO; INFLAMMATORY RESPONSE; CARDIOPULMONARY BYPASS; SIRP-ALPHA; DENDRITIC CELLS; POLY(CARBONATE URETHANE);
D O I
10.1177/1535370216647130
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Addressing the aberrant interactions between immune cells and biomaterials represents an unmet need in biomaterial research. Although progress has been made in the development of bioinert coatings, identifying and targeting relevant cellular and molecular pathways can provide additional therapeutic strategies to address this major healthcare concern. To that end, we describe the immune inhibitory motif, receptor-ligand pairing of signal regulatory protein alpha and its cognate ligand CD47 as a potential signaling pathway to enhance biocompatibility. The goals of this article are to detail the known roles of CD47-signal regulatory protein alpha signal transduction pathway and to describe how immobilized CD47 can be used to mitigate the immune response to biomaterials. Current applications of CD47-modified biomaterials will also be discussed herein.
引用
收藏
页码:1033 / 1041
页数:9
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