Transcriptional regulation of RANTES expression in T lymphocytes

被引：80

作者：

Song, A ^{[1
]}

Nikolcheva, T ^{[1
]}

Krensky, AM ^{[1
]}

机构：

[1] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

来源：

IMMUNOLOGICAL REVIEWS | 2000年 / 177卷

关键词：

D O I：

10.1034/j.1600-065X.2000.17610.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We first identified the RANTES chemokine as part of a search for genes expressed by T lymphocytes "late", 3-5 days, after T-cell activation. The kinetics of expression of RANTES and a small number of other genes are unusual and the mechanism of such delayed expression is unknown. In order to uncover a mechanism for such "late" expression, we identified and characterized the RANTES promoter and a novel transcription factor regulating RANTES expression in T lymphocytes. RANTES factor of late activated T lymphocytes (RFLAT)-1 is a member of the Kruppel-like family of transcription factors. Like RANTES, RFLAT-1 expression is "late" after T-cell activation. But, unlike RANTES, regulation of RFLAT-1 expression appears to be translational rather than transcriptional.

引用

页码：236 / 245

页数：10

共 53 条

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