Role of Decidual Natural Killer Cells at the Maternal-Fetal Interface during Pregnancy

被引：6

作者：

Yang, Shao-Liang ^{[1
]}

Wang, Hai-Yan ^{[2
]}

Li, Da-Jin ^{[1
]}

Li, Ming-Qing ^{[1
,3
]}

机构：

[1] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Inst Planned Parenthood Res, NHC Key Lab Reprod Regulat, 1326 Pingliang Rd, Shanghai 200080, Peoples R China

[2] Fudan Univ, Hosp Obstet & Gynecol, Dept Gynecol Integrated Tradit Chinese & Western, 128 Shenyang Rd, Shanghai 200011, Peoples R China

[3] Fudan Univ, Shanghai Key Lab Female Reprod Endocrine Related, Shanghai 200011, Peoples R China

来源：

REPRODUCTIVE AND DEVELOPMENTAL MEDICINE | 2019年 / 3卷 / 03期

关键词：

Decidual Natural Killer Cells; Maternal-Fetal Immune Tolerance; Vascular Remodeling; NK CELLS; IMMUNE CELLS; UTERINE; PHENOTYPE; MIGRATION; NEUTROPHILS; ACTIVATION; EXPRESSION; TOLERANCE; SURVIVAL;

D O I：

10.4103/2096-2924.268161

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Pregnancy is a complicated process with intricate cell-to-cell crosstalk and immune regulation. Decidual natural killer (NK) cells account for 50%-70% of decidual immune cells in early pregnancy, suggesting that they play important roles in various events, such as embryo implantation and vascular remodeling. Many studies have shown that decidual NK cells interact with other cells either through direct contact or the secretion factors such as cytokines and chemokines. Hence, this review aimed to present the phenotypic characteristics, classification, and functions of decidual NK cells at the maternal-fetal interface during pregnancy.

引用

页码：165 / 169

页数：5

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