An experimental Study on Protective Effect of Peiminine against Mechanical Ventilation-Induced Lung Injury in Mice

This work investigated the protective effects of peiminine on mechanical ventilation-induced lung injury (MVLI) in mice. Twenty-four mice were randomly divided into control, MVLI and peiminine groups. The peiminine group was treated with 1 mg/kg peiminine by gavage for seven days. Then, the MVLI model was constructed in MVLI and peiminine groups. After 4 h of mechanical ventilation, compared to MVLI group, in peiminine group the blood partial pressure of oxygen was significantly increased (p < 0.05), the total protein concentration and total cell number in bronchoalveolar lavage fluid were significantly decreased (p < 0.05), the lung wet/dry weight ratio was significantly decreased (p < 0.05), lung tissue tumor necrosis factor alpha and interleukin 1 beta levels were significantly decreased (p < 0.05), the lung tissue superoxide dismutase level was significantly increased (p < 0.05), and the lung tissue malondialdehyde level was significantly decreased (p < 0.05). In summary, the peiminine pretreatment can mitigate the MVLI in mice by inhibiting the inflammatory reaction and oxidative stress in lung tissue.