Learning from Leprosy: Insight into the Human Innate Immune Response

被引：44

作者：

Montoya, Dennis ^{[1
]}

Modlin, Robert L. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Dermatol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA

来源：

ADVANCES IN IMMUNOLOGY, VOL 105 | 2010年 / 105卷

关键词：

TOLL-LIKE RECEPTOR-2; SINGLE-NUCLEOTIDE POLYMORPHISMS; TUMOR-NECROSIS-FACTOR; MYCOBACTERIUM-TUBERCULOSIS INFECTION; DENDRITIC CELLS; CUTTING EDGE; INTRACELLULAR INFECTION; LEPROMATOUS LEPROSY; MICROBIAL LIPOPROTEINS; BACTERIAL LIPOPROTEINS;

D O I：

10.1016/S0065-2776(10)05001-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Investigation into the innate immune response in leprosy has provided insight into host defense and immunopathology in human infectious disease. A key advance has been the delineation of pattern recognition receptors that detect pathogen-associated molecular patterns of the bacterium that causes leprosy, Mycobacterium leprae. From this knowledge, it has been possible to determine the cytokine responses as well as macrophage and dendritic cell differentiation programs that contribute to host defense and tissue injury in leprosy. These insights provide targets for therapeutic intervention to modulate innate immune responses against microbial infection in humans.

引用

页码：1 / 24

页数：24

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