Specific Detection of Antibiotics by Silicon-on-Chip Photonic Crystal Biosensor Arrays

被引：19

作者：

Yan, Hai ^{[1
]}

Yang, Chun-Ju ^{[1
]}

Tang, Naimei ^{[2
]}

Zou, Yi ^{[1
]}

Chakravarty, Swapnajit ^{[2
]}

Roth, Amanda ^{[3
]}

Chen, Ray T. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Elect & Comp Engn, Microelect Res Ctr, Austin, TX 78758 USA

[2] Omega Opt Inc, Austin, TX 78757 USA

[3] Walter Reed Army Inst Res, Wound Infect Dept, Silver Spring, MD 20910 USA

来源：

IEEE SENSORS JOURNAL | 2017年 / 17卷 / 18期

关键词：

Photonic crystals; silicon photonics; optical biosensors; microcavities; antibiotics; WAVE-GUIDES; SENSITIVITY; VANCOMYCIN; AMINOGLYCOSIDES; RESONATORS; KINETICS; PLASMA; SENSOR;

D O I：

10.1109/JSEN.2017.2734885

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Photonic crystal (PC) microcavities formed by 2-D air holes on silicon-on-insulator substrates were utilized as biosensors to detect antibiotics with high specificity. The antibiotic, gentamicin, with molecular weight of only 478 g/mol, was successfully detected via its binding to corresponding antibody pre-immobilized on the sensor surface. Detection range (in concentration) was extended by combining different types of PC biosensors on a single silicon chip, covering from 0.1 nM to 1 mu M. Specificity of detection was also verified on the studied antibiotic.

引用

页码：5915 / 5919

页数：5

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