Synthesis of tritium labelled [2′,6′]-L-tyrosine

被引：9

作者：

Augustyniak, W ^{[1
]}

Kanski, R ^{[1
]}

Kanska, M ^{[1
]}

机构：

[1] Univ Warsaw, Dept Chem, PL-02089 Warsaw, Poland

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2004年 / 47卷 / 13期

关键词：

tritium; deuterium; tyrosine; enzyme; optical isotopomer;

D O I：

10.1002/jlcr.886

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of a specifically ring labelled isotopomer of L-tyrosine, (L-Tyr), using a combination of chemical and enzymatic methods is reported. The tritium labelled [2',6']-L-Tyr has been synthesized via catalytic exchange of phenol with tritiated water in the presence of K2PtCl4, reverse acid catalysed removal of tritium from the o- and p-positions of phenol, and subsequent condensation of the resulting [3',5-H-3(2)]-phenol with S-methyl-L-cysteine using the enzyme beta-tyrosinase from Citrobacter freundii. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：977 / 981

页数：5

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