共 18 条
Vascular Targeted Photodynamic Therapy with Padeliporfin for Low Risk Prostate Cancer Treatment: Midterm Oncologic Outcomes
被引:22
作者:

Lebdai, Souhil
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Angers, Dept Urol, Angers, France Univ Hosp Angers, Dept Urol, Angers, France

Bigot, Pierre
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Angers, Dept Urol, Angers, France Univ Hosp Angers, Dept Urol, Angers, France

Leroux, Pierre-Adrien
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Angers, Dept Urol, Angers, France Univ Hosp Angers, Dept Urol, Angers, France

Berthelot, Louis-Paul
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Angers, Dept Urol, Angers, France Univ Hosp Angers, Dept Urol, Angers, France

Maulaz, Pierre
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Angers, Dept Urol, Angers, France Univ Hosp Angers, Dept Urol, Angers, France

Azzouzi, Abdel-Rahmene
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Angers, Dept Urol, Angers, France Univ Hosp Angers, Dept Urol, Angers, France
机构:
[1] Univ Hosp Angers, Dept Urol, Angers, France
关键词:
prostatic neoplasms;
photochemotherapy;
WST11;
compound;
therapeutic occlusion;
treatment outcome;
WST11;
MODEL;
TOOKAD((R));
ABLATION;
EFFICACY;
SAFETY;
D O I:
10.1016/j.juro.2017.03.119
中图分类号:
R5 [内科学];
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号:
1002 ;
100201 ;
摘要:
Purpose: We assessed the midterm oncologic outcomes of vascular targeted photodynamic therapy with padeliporfin for low risk prostate cancer treatment. Materials and Methods: We prospectively assessed all patients treated with vascular targeted photodynamic therapy for low risk prostate cancer at our center. Patients were followed every 6 months. All patients underwent prostate biopsies 6 months after treatment or when there was biological or clinical progression. The primary end point was progression-free survival. Secondary end points were absent clinically significant cancer in the treated lobes, radical therapy and the prostate specific antigen rate. Variables were compared with the chi-square, Mann-Whitney or Wilcoxon test. Progression-free survival is reported with Kaplan-Meier curves. Results: A total of 82 men were treated with vascular targeted photodynamic therapy. Median followup was 68 months (range 6 to 89). Median progressionfree survival was 86 months (95% CI 82-90). Median prostate specific antigen decreased significantly by 41% 6 months after treatment and it remained stable during followup (p < 0.001). A total of 115 lobes were treated and absent clinically significant cancer was achieved in 94 (82%). Of the 82 patients 20 (24%) underwent radical therapy, including radical prostatectomy in 18 and brachytherapy in 2, at a median of 22 months (range 6 to 86). Study limitations include a single arm design, small population size and midterm followup. Conclusions: Padeliporfin vascular targeted photodynamic therapy for low risk prostate cancer achieved an 82% rate of absent clinically significant cancer in treated lobes and 76% of patients avoided radical therapy at a median followup of 68 months. However, longer followup is required to determine long-term outcomes.
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页码:335 / 343
页数:9
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