An easy and fast ultrasonic selective S-alkylation of hetaryl thiols at room temperature

被引：32

作者：

Deligeorgiev, Todor ^{[1
]}

Kaloyanova, Stefka ^{[1
]}

Lesev, Nedyalko ^{[1
]}

Vaquero, Juan J. ^{[2
]}

机构：

[1] Univ Sofia, Fac Chem, Sofia 1164, Bulgaria

[2] Univ Alcala de Henares, Fac Farm, Madrid 28871, Spain

来源：

ULTRASONICS SONOCHEMISTRY | 2010年 / 17卷 / 05期

关键词：

Selective S-alkylation; Mercaptoazoles; Ultrasound irradiation; EFFICIENT METHOD; SUPPORTED SYNTHESIS; DERIVATIVES; 2-MERCAPTOBENZIMIDAZOLE; CONVENIENT; 2-MERCAPTOBENZOTHIAZOLE; INHIBITION; REACTIVITY; THIOETHERS; BENZAZOLE;

D O I：

10.1016/j.ultsonch.2010.03.002

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

A series of 2-alkylthio derivatives of hetaryl thiols were synthesized by selective S-alkylation with alkyl halides (bromides and iodides) with ultrasonic irradiation at room temperature. The reaction was found to be generally applicable to hetaryl thiol derivatives with different substituents in the aromatic nucleus and various alkyl halides. The reaction gives high to excellent yields of products with high purity. (C) 2010 Elsevier B.V. All rights reserved.

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页码：783 / 788

页数：6

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