Immunity to sternness genes in human cancer

被引：22

作者：

Dhodapkar, Madhav V. ^{[1
,2
]}

机构：

[1] Yale Univ, Sect Hematol, New Haven, CT 06510 USA

[2] Yale Univ, Immunobiol Sect, New Haven, CT 06510 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 02期

基金：

美国国家卫生研究院;

关键词：

PLURIPOTENT STEM-CELLS; ACUTE MYELOID-LEUKEMIA; POTENTIAL TARGET; IPS CELLS; ANTIGEN; TUMOR; IDENTIFICATION; IMMUNOTHERAPY; BREAST; EXPRESSION;

D O I：

10.1016/j.coi.2010.01.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A growing body of data points to not only intraclonal heterogeneity and hierarchy of growth potential, but also plasticity of cellular differentiation within human tumors. Recent studies have also identified surprising overlap between pathways that regulate pluripotency in embryonal stem (ES) cells and oncogenesis. While there is a long history of targeting embryonal tissues toward cancer vaccines, recent identification of crucial sternness pathways in ES cells as well as putative cancer stern cells (CSCs) provides novel opportunities for antigen-specific targeted therapy. Here we discuss recent insights into the capacity of the immune system to target these pathways. Immunologic targeting of pathways associated with sternness has implications for both immune regulation of tumor growth as well as regenerative therapies with embryonal stem cells.

引用

页码：245 / 250

页数：6

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