Finding useful biomarkers for Parkinson's disease

被引：89

作者：

Chen-Plotkin, Alice S. ^{[1
]}

Albin, Roger ^{[2
,3
,4
]}

Alcalay, Roy ^{[5
]}

Babcock, Debra ^{[6
]}

Bajaj, Vikram ^{[7
]}

Bowman, Dubois ^{[8
]}

Buko, Alex ^{[9
]}

Cedarbaum, Jesse ^{[10
]}

Chelsky, Daniel ^{[11
]}

Cookson, Mark R. ^{[12
]}

Dawson, Ted M. ^{[13
]}

Dewey, Richard ^{[14
]}

Foroud, Tatiana ^{[15
]}

Frasier, Mark ^{[16
]}

German, Dwight ^{[17
]}

Gwinn, Katrina ^{[6
]}

Huang, Xuemei ^{[18
]}

Kopil, Catherine ^{[16
]}

Kremer, Thomas ^{[19
]}

Lasch, Shirley ^{[20
]}

Marek, Ken ^{[20
]}

Marto, Jarrod A. ^{[21
,22
,23
,24
]}

Merchant, Kalpana ^{[25
]}

Mollenhauer, Brit ^{[26
,27
]}

Naito, Anna ^{[16
]}

Potashkin, Judith ^{[28
]}

Reimer, Alyssa ^{[16
]}

Rosenthal, Liana S. ^{[29
]}

Saunders-Pullman, Rachel ^{[30
]}

Scherzer, Clemens R. ^{[31
]}

Sherer, Todd ^{[16
]}

Singleton, Andrew ^{[32
]}

Sutherland, Margaret ^{[6
]}

Thiele, Ines ^{[33
]}

van der Brug, Marcel ^{[34
]}

Van Keuren-Jensen, Kendall ^{[35
]}

Vaillancourt, David ^{[36
]}

Walt, David ^{[24
]}

West, Andrew ^{[37
]}

Zhang, Jing ^{[38
]}

机构：

[1] Univ Penn, Dept Neurol, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] VAAHS, Neurol Serv, Ann Arbor, MI 48105 USA

[3] VAAHS, GRECC, Ann Arbor, MI 48105 USA

[4] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA

[5] Columbia Univ, Dept Neurol, Med Ctr, New York, NY 10032 USA

[6] NINDS, NIH, Bethesda, MD 20824 USA

[7] Verily Google Life Sci, San Francisco, CA 94080 USA

[8] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA

[9] Human Metabolome Technol Amer, Boston, MA 02134 USA

[10] Biogen, Cambridge, MA 02142 USA

[11] Caprion Biosci, Montreal, PQ H2X 3Y7, Canada

[12] NIA, Cell Biol & Gene Express Sect, Lab Neurogenet, NIH, Bethesda, MD 20892 USA

[13] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21205 USA

[14] Univ Texas Southwestern Med Ctr, Dept Neurol & Neurotherapeut, Dallas, TX 75390 USA

[15] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

[16] Michael J Fox Fdn Parkinsons Res, New York, NY 10163 USA

[17] Univ Texas Southwestern Med Ctr, Dept Psychiat, Dallas, TX 75390 USA

[18] Penn State Univ, Hershey Med Ctr, Dept Neurol, Hershey, PA 17033 USA

[19] F Hoffmann La Roche Ltd, Pharmaceut Res & Early Dev, NORD Discovery & Translat Area, Roche Innovat Ctr Basel, CH-4070 Basel, Switzerland

[20] Inst Neurodegenerat Disorders, New Haven, CT 06510 USA

[21] Harvard Med Sch, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA

[22] Harvard Med Sch, Dana Farber Canc Inst, Dept Pathol, Boston, MA 02215 USA

[23] Harvard Med Sch, Blais Prote Ctr, Dana Farber Canc Inst, Boston, MA 02215 USA

[24] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02215 USA

[25] Chaperone Therapeut, Portland, OR 97229 USA

[26] Paracelsus Elena Klin, D-34128 Kassel, Germany

[27] Univ Med Ctr, D-37075 Gottingen, Germany

[28] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Cellular & Mol Pharmacol, Chicago, IL 60064 USA

[29] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[30] Icahn Sch Med Mt Sinai, Mt Sinai Beth Israel, Dept Neurol, New York, NY 10003 USA

[31] Harvard Med Sch, Ctr Adv Parkinsons Dis Res & Precis Neurol Progra, Brigham & Womens Hosp, Boston, MA 02115 USA

[32] NIA, Lab Neurogenet, Bethesda, MD 20892 USA

[33] Univ Luxembourg, Luxembourg Ctr Syst Biomed, Luxembourg, Luxembourg

[34] Genentech Inc, San Francisco, CA 94080 USA

[35] Translat Genom Res Inst, Neurogen Div, Phoenix, AZ 85004 USA

[36] Univ Florida, Dept Appl Physiol Biomed Engn & Neurol, Gainesville, FL 32611 USA

[37] Univ Alabama Birmingham, Dept Neurol, Birmingham, AL 35233 USA

[38] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2018年 / 10卷 / 454期

关键词：

PLASMA APOLIPOPROTEIN A1; ALZHEIMERS-DISEASE; DISCOVERY; DISORDERS; SERUM; BETA;

D O I：

10.1126/scitranslmed.aam6003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recent advent of an "ecosystem" of shared biofluid sample biorepositories and data sets will focus biomarker efforts in Parkinson's disease, boosting the therapeutic development pipeline and enabling translation with real-world impact.

引用

页数：8

共 33 条

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